Correlation among electrocardiogram changes, cardiac troponin Ⅰ level and prognosis of patients with unstable angina

Sun Ping; Xue Feng; Qin Yuehua

doi:10.3760/j.issn.1673-4777.2018.05.009

Abstract：Objective To explore the correlation among electrocardiogram changes,cardiac troponin Ⅰ (cTnⅠ) level and prognosis of patients with unstable angina.Methods Totally 156 patients with unstable angina were enrolled from July 2015 to December 2016 in Affiliated Hospital of Nantong University.Level of cTnⅠ was tested and the patients were divided into cTnⅠ ≥ 0.16 mg/L group and cTnⅠ ＜ 0.16 mg/L group.According to electrocardiogram(ECG) characteristics,the patients were divided into ST-segment elevation group,ST-segment depression group,simple T wave inversion group and normal ECG group.Occurrence of major adverse cardiac events (MACE) was recorded in 30 d after admission.The correlation among cTnⅠ level,electrocardiographic characteristics and MACE was analyzed.Results There were 61 cases of cTnⅠ≥0.16 mg/L and 123 cases of ECG abnormality.MACE occurred in 28 patients.Electrocardiographic abnormality rate in cTnⅠ ≥0.16 mg/L group was significantly higher than that in cTnⅠ ＜0.16 mg/L group[95.1％ (58/61) vs 68.4％ (65/95)] (x2 =26.007,P ＜ 0.001).MACE rate in cTnⅠ ≥0.16 mg/L group was significantly higher than that in cTnⅠ ＜0.16 mg/L group[19.7％ (14/61) vs 4.2％ (4/95)] (x2 =12.781,P ＜ 0.001).MACE rates in ST-segment elevation group,ST-segment depression group,simple T wave inversion group and normal ECG group were 34.8％ (8/23),13.8％ (4/29),7.0％ (5/71) and 3.0％ (1/33),respectively;there were significant differences among groups (P ＜ 0.001).Binomial logistic regression analysis showed that cTnⅠ ≥ 0.16 mg/L (odds ratio =19.717,P ＜ 0.001,95％ confidence interval:5.668-68.589) and ECG abnormality(odds ratio =0.036,P =0.002,95％ confidence interval:0.004-0.302) were independent risk factors of early prognosis of unstable angina.Conclusion The level of cTnⅠ is related with ECG abnormality and both of them are independent risk factors of early prognosis of unstable angina.