Effect of levamlodipine besylate combined with Jiangya Yishen granules on primary hypertension

Wei Jingmei; Ma Yuhua

doi:10.3760/j.issn.1673-4777.2018.05.006

Abstract：Objective To investigate the clinical effect of levamlodipine besylate combined with Jiangya Yishen granules on primary hypertension.Methods A total of 98 patients with primary hypertension admitted from November 2015 to April 2017 in Qinghai Province Cardiovascular and Cerebrovascular Disease Hospital were randomly divided into control group and observation group(n =49).The control group took levamlodipine besylate tablets;the observation group took levamlodipine besylate tablets and Jiangya Yishen granules.Changes of blood pressure,levels of serum platelet derived growth factor-BB(PDGF-BB) and resistin,quality of life(SF-36) score and adverse reactions were analyzed.Results Before treatment,systolic pressure and diagnostic pressure had no significant differences between groups (P ＞ 0.05).After treatment,systolic pressure and diagnostic pressure decreased compared to those before treatment and there were significant differences between observation group and control group [(127 ± 12) mmHg vs (140 ± 12) mmHg,(68 ± 10) mmHg vs (76 ± 11) mmHg] (P ＜ 0.05).Before treatment,levels of serum PDGF-BB and resistin had no significant differences between groups(P ＞ 0.05).After treatment,resistin level significantly decreased in both groups and PDGF-BB level significantly decreased in observation group(P ＜0.05);levels of serum PDGF-BB and resistin in observation group were significantly lower than those in control group [(18 ± 7) μg/L vs (23 ± 10) μg/L,(0.25 ± 0.11) mmol/L vs (0.48 ± 0.15) mmol/L] (P ＜ 0.05).After treatment,SF-36 scores in both observation and control groups significantly increased compared to those before treatment [(76 ± 6) vs (64 ± 6),(85 ± 6) vs (65 ± 5)];SF-36 score in observation group was significantly higher than that in control group(P ＜0.001).The total effective rate in observation group was significantly higher than that in control group[91.8％ (45/49) vs 71.4％ (35/49)] (x2 =6.806,P =0.009).The incidence rate of adverse reactions showed no significant difference between groups (P ＞ 0.05).Conclusion Levamlodipine besylate combined with Jiangya Yishen granules treating primary hypertension can effectively reduce blood pressure,serum levels of PDGF-BB and resistin,improve therapeutic effect and quality of life.