Relation between high-density lipoprotein cholesterol level and severity of complex coronary artery disease
Huang Ji
Hao Zhongling
Li Zhao
Li Nan
Lin Yun
Zhang Jingmei
Li Zhizhong
Abstract：Objective To investigate the relation between high-density lipoprotein cholesterol (HDL-C) level and the severity of coronary lesions in patients with complex coronary artery disease.Methods Clinical records of 633 patients with complex coronary artery disease (observation group) and 580 patients with simple coronary artery disease (control group) diagnosed by coronary angiography from January 2013 to July 2016 in Beijing Anzhen Hospital,Capital Medical University were analyzed.The relation between HDL-C level and coronary artery lesions was analyzed.Result Male rate,body mass index,previous history of myocardial infarction rate,smoking rate and the Gensini score in observation group were significantly higher than those in control group;HDL-C level and left ventricular ejection fraction in observation group were significantly lower than those in control group[79.9％ (506/633) vs 69.0％ (400/580),(24 ± 3) kg/m2 vs (23 ± 3) kg/m2,27.2％ (172/633) vs 16.9％ (98/580),86.1％(545/633) vs 82.6％(479/580),32(16,56) vs 20(8,28),0.91(0.79,1.07)mmol/L vs 0.98 (0.84,1.18) mmol/L,64 (58,68) ％ vs 65 (60,68) ％] (P ＜ 0.05).Logistic regression analysis showed that HDL-C level was an independent risk factor of complex coronary artery disease (odds ratio:0.421,95％ confidence interval:0.275-0.646,P ＜0.001).Spearman correlation analysis showed that HDL-C level was negatively related to the Gensini score(r =-0.247,P =0.019).Conclusion Low HDL-C level is a visk factor of complex coronary artery disease.
Keywords：Complex coronary artery diseaseHigh-density lipoprotein cholesterol
Publication Date：2018-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 656-659 )