Effect of enhanced dose atorvastatin on serum lipid and high-sensitivity C-reactive protein in elderly patients after coronary intervention

Liu Changyu; Su Yu; Wu Liting

doi:10.3760/j.issn.1673-4777.2018.05.004

Abstract：Objective To analyze the effect of enhanced dose atorvastatin on serum lipid and high-sensitivity C-reactive protein(hs-CRP) in elderly patients after percutaneous coronary intervention(PCI).Methods A total of 68 cornary heart disease patients undergoing PCI from July 2016 to July 2017 in Hainan General Hospital were randomly divided into observation group(n =34) and control group(n =34).The control group took atorvastatin 10 mg every evening;the observation group took atorvastatin 80 mg every evening.Levels of total cholesterol,triacylglycerol,low-density lipoprotein cholesterol (LDL-C),high-density lipoprotein cholesterol (HDL-C) and hs-CRP were analyzed before and after treatment.Results There were no significant differences of total cholesterol,triacylglycerol,LDL-C and HDL-C levels between groups before treatment (P ＞ 0.05).After treatment,levels of total cholesterol,triacylglycerol and LDL-C were significantly lower and HDL-C was significantly higher than those before treatment in both groups;levels of total cholesterol and LDL-C in observation group were significantly lower and HDL-C was significantly higher than those in control group(P ＜ 0.05).Level of hs-CRP before treatment had no significant difference between observation group and control group[(11.2 ±5.2) mg/L vs (10.8 ±5.1) mg/L] (P ＞ 0.05).After treatment,level of hs-CRP was significantly lower than that before treatment in both groups;level of hs-CRP in observation group [(4.2 ± 1.8) mg/L] was significantly lower than that in control group [(7.0 ± 2.9) mg/L] (P ＜ 0.05).Conclusion Enhanced dose atorvastatin treating elderly patients after PCI can effectively reduce serum lipid,hs-CRP level and improve the anti-inflammatory action.