Efficacy and safety of self-made Shuwei Hegan powders in treatment of precancerous lesion of chronic atrophic gastritis

Guo Zhongcong; Wen Jing

doi:10.3760/cma.j.issn.1673-4777.2018.04.019

Abstract：Objective To observe the efficacy and safety of self-made Shuwei Hegan powders in treatment of precancerous lesion of chronic atrophic gastritis(CAG).Methods Totally 78 patients with CAG precancerous lesion at the First Affiliated Hospital of Hunan University of Chinese Medicine from January 2016 to June 2017 were randomly divided into control group and observation group,with 39 cases in each group.The control group took folic acid tablets and Weifuchun tablets;the observation group was treated by Shuwei Hegan powders.After 6 months of treatment,clinical efficacy,motilin and gastrin,histopathological and gastroscopic results,traditional Chinese medicine(TCM) syndrome features and adverse reactions were analyzed.Results In control group,the cure rate was 33.3％ (13/39);the obvious effective rate was 15.4％ (6/39);the effective rate was 12.8％ (5/39);the ineffective rate was 38.5％ (15/39).In observation group,the cure rate was 48.7％ (19/39);the obvious effective rate was 23.1％ (9/39);the effective rate was 15.4％ (6/39);the ineffective rate was 12.8％ (5/39).Clinical efficacy in observation group was significantly better than that in control group (P =0.030).After treatment,serum levels of motilin and gastrin were significantly higher than those before treatment in both groups;serum levels of motilin and gastrin in observation group were significantly higher than those in control group (P ＜0.001).Pathological scores of inflammatory lesion,atrophy,intestinal metaplasia and dysplasia after treatment were significantly lower than those before treatment in both groups;pathological scores of inflammatory lesion,atrophy,intestinal metaplasia and dysplasia after treatment in observation group were significantly lower than those in control group(P ＜ 0.001).Incidences of ulcer,erosion,bile regurgitation and blood spots under gastroscope after treatment in observation group were significantly lower than those in control group[10.3％ (4/39) vs 30.8％(12/39),12.8％ (5/39) vs 33.3％ (13/39),5.1％ (2/39) vs 23.1％ (9/39),7.7％ (3/39) vs 25.6％ (10/39)](P ＜ 0.05).TCM syndrome scores of gastric abscess,distention and fullness,noisy,weakness,digestive dysfunction after treatment were significantly lower than those before treatment in both groups;TCM syndrome scores of gastric abscess,distention and fullness,noisy,weakness,digestive dysfunction after treatment in observation group were significantly lower than those in control group(P ＜0.001).No severe adverse reaction was observed in both groups.Conclusion Shuwei Hegan powders treating CAG precancerous lesion can effectively and safely improve serum gastrin,motilin secretion and promote mucosal healing.