Effect of reduced glutathione combined with alteplase on reperfusion in elderly patients with acute myocardial infarction
Wang Yihan
Yao Yumeng
Fan Liping
Han Ying
Abstract：Objective To explore the effect of reduced glutathione (GSH) combined with alteplase on reperfusion in elderly patients with acute myocardial infarction.Methods Totally 116 elderly patients with acute myocardial infarction admitted from January 2015 to January 2017 in the First Affiliated Hospital of Harbin Medical University were randomly divided into observation group and control group,with 58 cases in each group.The control group had alteplase reperfusion therapy;the observation group had GSH combined with alteplase reperfusion therapy.Laboratory indicators,cardiac function indexes and adverse reactions were analyzed.Results Total effective rate in observation group was significantly higher than that in control group [96.6％ (56/58) vs 81.0％ (47/58)] (P =0.006).Before treatment,there was no significant difference of cardiac troponin T,creatine kinase isoenzyme,cardiac troponin I,superoxide dismutase and GSH between groups(P ＞ 0.05).After treatment,cardiac troponin T and cardiac troponin I in observation group were significantly lower than those in control group [(0.764 ± 0.283) U/L vs (1.242 ± 0.442) U/L,(0.752 ± 0.343) μg/L vs (1.521 ± 0.572) μg/L];creatine kinase isoenzyme,superoxide dismutase and GSH in observation group were significantly higher than those in control group[(30 ±4)U/L vs (23 ±3) U/L,(77 ±8)U/L vs (65 ±6) U/L,(856 ±68) U/L vs (659 ±57) U/L](all P ＜ 0.05).Before treatment,there was no significant difference of left ventricular end-systolic diameter,left ventricular end-diastolic diameter and left ventricular ejection fraction between groups(P ＞ 0.05).After treatment,left ventricular end-systolic diameter and left ventricular end-diastolic diameter were significantly lower than those before treatment and left ventricular ejection fraction was significantly higher than that before treatment in both groups;left ventricular end-systolic dimension and left ventricular end-diastolic dimension in observation group were significantly lower than those in control group[(40 ±7)mm vs (50 ±8)mm,(51 ±5)mm vs (60 ±8)mm];left ventricular ejection fraction in observation group was significantly higher than that in control group [(74 ±10) ％ vs (59 ± 9)％] (all P ＜ 0.05).Incidence rate of adverse reactions in observation group was significantly lower than that in control group [5.2％ (3/58) vs 24.1％ (14/58)] (P ＜ 0.05).Conclusion GSH combined with alteplase treating elderly patients with acute myocardial infarction can promote reperfusion,reduce myocardial reperfusion injury,improve heart function and reduce adverse reactions.
Keywords：Acute myocardial infarctionReperfusionReduced glutathioneAlteplase
Publication Date：2018-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 499-503 )