Effect of metoprolol succinate on heart failure with preserved ejection fraction
Han Leisen
Abstract：Objective To assess the effect of metoprolol succinate on heart failure with preserved ejection fraction.Methods Totally 104 patients diagnosed of heart failure with preserved ejection fraction from May 2013 to April 2017 in the Fourth People's Hospital of Shaanxi were randomly divided into group A and B,with 52 patients in each group.The group B took metoprolol succinate and the group A took equivalent placebo.Heart function was assessed by the New York Heart Association (NYHA) classification 24 weeks after treatment.Exercise capacity,echocardiogram parameters,levels of N-terminal pro-brain natriuretic peptide and procollagen type Ⅰ carboxy-terminal extension peptide (PICP) and scores of life quality were analyzed.Results After treatment,improvement ratio of the NYHA classification in group B was significantly higher than that in group A [32.7％ (17/52) vs 11.5％ (6/52)] (P ＜ 0.05).Changes of exercise capacity,left ventricular mass,left ventricular end-diastolic volume,left ventricular end-systolic volume and PICP level in group B were more significant than those in group A(P ＜ 0.05).Improvements of physical function,emotional health,society function and general health scores in group B were more significant than those in group A (P ＜ 0.05).Conclusion Metoprolol succinate shows good therapeutic effect on heart failure with preserved ejection fraction.
Keywords：Heart failureMetoprolol succinate
Publication Date：2018-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 492-495 )