Therapeutic effect and safety of levosimendan on elderly patients with acute myocardial infarction complicated with heart failure
Zhang Qian
Guo Chang
Wei Lujia
Yao Wei
Wang Xifu
Zhang Huimin
Song Huifen
Tian Xue
Wang Yu
Shi Shutian
Wang Chunmei
Nie Shaoping
Abstract：Objective To observe the therapeutic effect and safety of levosimendan on elderly patients with acute myocardial infarction complicated with heart failure.Methods Totally 346 elderly patients with acute myocardial infarction complicated with heart failure were enrolled from January 2016 to June 2017 in Beijing Anzhen Hospital,Capital Medical University.Conventional treatments including antiplatelet,anticoagulant,diuretic,vasodilative and symptomatic treatments were performed in 219 patients (control group).Intravenous injection of levosimendan combined with conventional treatments were performed in 127 patients (observation group).Vital signs,heart function and major adverse cardiovascular events were analyzed.Results Twenty-four hours after treatment,heart rate,systolic pressure and respiratory rate were significantly lower than those before treatment in both groups;heart rate and respiratory rate in observation group were significantly lower than those in control group[(84 ± 8)times/min vs (92 ± 9) times/min,(21 ± 3) times/min vs (24 ± 4) times/min] (P ＜ 0.05).One week after treatment,serum creatinine level in observation group was significantly lower than that in control group [(81 ± 16) μmol/L vs (94 ±17)μmol/L] (P ＜ 0.05);levels of B-type natriuretic peptide and high-sensitive C-reactive protein were significantly lower than those before treatment in both groups;levels of B-type natriuretic peptide and high-sensitive C-reactive protein in observation group were significantly lower than those in control group;left ventricular ejection fraction and left ventricular shortening fraction in observation group were significantly lower than those in control group and those before treatment(all P ＜ 0.05).Heart failure aggravation rate and mortality rate in 1 week in observation group were significantly lower than those in control group (P ＜ 0.05).Conclusion Levosimendan is effective and safe in treating elderly patients with acute myocardial infarction complicated with heart failure.
Keywords：Acute myocardial infarctionHeart failureLevosimendan
Publication Date：2018-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 481-484 )