Risk factors of gastrointestinal bleeding caused by aspirin in patients with type 2 diabetes mellitus
Liu Junwei
Li Hongmei
Deng Aimin
Abstract：Objective To analyze the risk factors of gastrointestinal bleeding caused by aspirin in patients with type 2 diabetes mellitus.Methods Totally 1 087 type 2 diabetic patients admitted from January 1 st,2011 to June 31st,2017 in General Hospital of Guangzhou Military Command of People's Liberation Army were retrospectively analyzed;all patients took bayaspirin enteric-coated tablets 100 mg/time,1 time/d.Gastrointestinal bleeding occurred in 152 cases(bleeding group)and 935 cases were non-bleeding group.Related indicators of aspirin-induced gastrointestinal bleeding were analyzed by single-factor test and logistic regression test.Results Age,smoking ratio,alcohol-drinking ratio and gastrointestinal disease ratio in bleeding group were significantly higher than those in non-bleeding group[(70 ± 11) years vs (65 ± 12) years,74.3％ (113/152) vs 63.4％ (593/935),40.8％(62/152) vs 25.8％ (241/935),18.4％ (28/152) vs 7.8％ (73/935)] (P ＜0.05).Logistic regression showed that advanced age(odds ratio =2.559,P =0.030,95％ confidence interval:1.093-5.989) and alcohol-drinking (odds ratio =2.039,P =0.023,95％ confidence interval:1.102-3.771) were risk factors of aspirin-induced gastrointestinal bleeding.Conclusion Advanced age and alcohol-drinking are risk factors of gastrointestinal bleeding caused by aspirin in patients with type 2 diabetes mellitus.
Keywords：Type 2 diabetes mellitusGastrointestinal bleedingAspirinRisk factors
Publication Date：2018-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 397-399 )