A meta analysis of vancomycin intravenous drip infusion and intrathecal injection combined with intravenous drip infusion in treatment of intracranial infection
Wang Qiuyan
Liu Ruming
He Jin
Wang Xi
Zhang Jun
Abstract：Objective To analyze the efficacy and safety of vancomycin intravenous drip infusion and intravenous drip infusion combined with intrathecal injection in treatmem of imracranial infection.Methods Casecontrol studies about vancomycin intravenous drip infusion and intrathecal injection combined with intravenous drip infusion treating intracranial infection were searched in Pubmed,Cochrane Library,Elsevier Clinical Key,FMJS,Chinese Journal Full-text Database,Chinese Biomedical Literature Database,Wanfang Database and VIP Database until June 2017.Revman 5.3 software was used for data analysis.Results Five respective cohort studies including 248 patients were reviewed;112 patients were treated by intravenous drip infusion of vancomycin;136 patients were treated by vancomycin via intravenous drip infusion combined with intrathecal injection.Meta analysis showed that the clinical effective rate(odds ratio =6.24,95％ confidence interval:2.68-14.54,P ＜0.001) and healing time(odds ratio =-4.78,95％ confidence interval:-7.59 to-1.96,P ＜ 0.001) had significant differences between intravenous drip infusion group and intravenous drip infusion combined with intrathecal injection group;adverse drug reactions showed no significant difference between groups[OR =1.38,95％ confidence interval:0.43-4.50,P =0.59].Conclusion Vancomycin intravenous drip infusion combined with intrathecal injection treating intracranial infection is better than intravenous drip infusion in improving clinical efficacy and shortening cure time without increasing adverse reaction.
Keywords：Intracranial infectionVancomycinIntravenous drip infusionIntrathecal injectionMeta analysis
Publication Date：2018-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 388-392 )