Bacterial distribution and drug resistance characteristics among hospitalized patients in respiratory and critical care medicine department from 2011 to 2016
Wu Yuanxing
Liu Yulei
Wang Aiping
Zhu Guangfa
Abstract：Objective To investigate bacterial distribution and drug resistance characteristics among hospitalized patients in respiratory and critical care medicine depaetnent from 2011 to 2016.Methods Bacteriological records and antimicrobial susceptibility test results of samples separated from hospitalized patients in Department of Respiratory and Critical Care Medicine,Beijing Anzhen Hospital,Capital Medical University were collected from January 2011 to December 2016;bacterial distribution and drug resistance characteristics were analyzed between time period Ⅰ (2011 to 2013) and time period Ⅱ1 (2014 to 2016).Results A total of 3 249 bacterial strains were isolated from 2011 to 2016;the top 3 bacterial sources were respiratory tract [3 028 (93.20％)],blood [93 (2.86％)] and urine [61 (1.88％)].Gram-negative bacteria accounted for 2 907 (89.47％),including Acinetobacter baumannii [931 (32.03％)],Klebsiella pneumoniae [558 (19.19％)],Pseudomonas aeruginosa [521 (17.92％)],Stenotrophomonas maltophilia[187(6.43％)],Enterobacter[165(5.68％)],Escherichia coli [114(3.92％)] and others[431 (14.83％)].Gram-positive bacteria accounted for 342(10.53％),including Coagulase-negative staphylococci [128 (37.4％)],Staphylococcus aureus [107 (31.3％)],Enterococcus [39(11.4％)] and others[68 (19.9％)].Drug resistance rates of Acinetobacter baumannii to amikacin,levofloxacin and tetracycline in time period Ⅱ1 were significantly higher than those in time period Ⅰ (P ＜ 0.05).Drug resistance rate of Staphylococcus aureus to penicillin was 100.0％;sensitivity rate of Staphylococcus aureus to vancomycin was 100.0％;resistance rate of Staphylococcus aureus to linezolid was ＜ 10％.Drug resistance rate of Coagulase-negative staphylococci to penicillin was ＞ 98％;resistance rates of Coagulase-negative staphylococci to vancomycin and linezolid were ＜ 10％.Conclusion Bacterial distribution and drug resistance monitoring is important for rational use of antibacterials.
Keywords：Respiratory and critical care medicine BacteriaResistanceAntibacterialsInfection
Publication Date：2018-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 383-387 )