Clinical effect of high dose tigecycline on ventilator associated pneumonia caused by multi-drug resistant bacteria
Zang Huiling
Wang Shengchi
Cheng Hui
Abstract：Objective To observe the clinical effect of high dose tigecycline on ventilator associated pneumonia(VAP) caused by multi-drug resistant(MDR) bacteria.Methods Records of 21 MDR VAP patients treated by high dose tigecycline and 28 MDR VAP patients treated by meropenem admitted in the First Hospital of Shijiazhuang from June 2011 to April 2016 were reviewed.Clinical efficacy,bacterial clearance rate,antibacterial drug use time,hospital stay time and adverse reactions were analyzed.Results Therapeutic effective rate and bacterial clearance rate in tigecycline group were significantly higher than those in meropenem group[76.2％ (16/21) vs 35.7％ (10/28),57.1％ (12/21) vs 32.1％ (9/28)] (P ＜0.01 or P ＜0.05).Antibacterial drug use time and hospital stay time in tigecycline group were significantly shorter than those in meropenem group [(12 ± 3) d vs (14±3)d,(15 ± 4)d vs (21 ± 5)d] (P ＜ 0.01).No obvious adverse reaction occurred in both groups.Conclusion High dose tigecycline has good efficacy and safety in treatment of MDR VAP.
Keywords：Ventilator associated pneumoniaHigh dose tigecyclineMulti-drug resistant bacteria
Publication Date：2018-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 380-382 )