Clinical characteristics of myeloproliferative neoplasms complicated with acute myocardial infarction
Zhao Sen
Bai Beibei
Han Xue
Chen Ye
Abstract：Objective To analyze the clinical characteristics of myeloproliferative neoplasms (MPN) complicated with acute myocardial infarction(AMI).Methods Twenty-two patients suffering from AMI complicated with MPN,including 6 patients with polycythemia vera(PV) and 16 patients with essential thrombocythemia(ET),were enrolled from April 2007 to May 2017 in Beijing Anzhen Hospital,Capital Medical University.Results of routine blood test,electrocardiography,coronary angiography,color Doppler ultrasonography,therapeutic plans and outcomes were analyzed.Results In 22 patients with AMI complicated with MPN,14 cases(63.6％) were diagnosed of AMI and MPN concurrently;8 patients(36.4％) developed AMI after the diagnosis of MPN.There were 13 cases of ET with ST-segment elevation myocardial infarction and 2 cases of ET with non-ST-segment elevation myocardial infarction;the type of AMI in 1 patient with ET was unclear.There were 5 cases of PV with ST-segment elevation myocardial infarction and 1 case of PV with unclear type myocardial infarction.Coronary angiography showed 9 cases of single vessel lesion and 7 cases of multiple vessel lesions in ET with AMI;there were 2 cases of single vessel lesion and 4 cases of multiple vessel lesions in PV with AMI.Twenty-one patients had coronary revascularization and anti-platelet therapy.Nine patients had cytoreductive therapy before revascularization;5 patients received cytoreductive therapy after revascularization.Three patients who did not have cytoreductive therapy before revascularization had recurrent coronary disease in 3 months after operation.One patient without coronary revascularization had recurrent AMI in 1 year.Conclusions AMI patients with abnormal complete blood count have a high possibility of MPN.AMI with MPN is mostly seen in male patients under 60 years old.The onset age of MPN is younger than that of coronary heart disease in female patients.MPN is lack of characteristic symptoms;clinical treatments mainly include cytoreductive,antiplatelet therapy and coronary revascularization.
Keywords：Acute myocardial infarctionMyeloproliferative neoplasmsThrombosis
Publication Date：2018-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 346-349 )