Effect of 15 mg rosuvastatin on blood lipid and carotid plaque in patients with very high cardiovascular risk
Wu Wenfa
Yu Huiwen
Deng Wanqing
Abstract：Objective To investigate the effect and safety of 15 mg rosuvastatin on blood lipid level and carotid plaque in patients with very high cardiovascular risk.Methods Totally 320 newly diagnosed carotid plaque patients with very high risk of cardiovascular diseases were enrolled from January 2014 to January 2016 in Guangzhou Red Cross Hospital to randomly have 10 mg dose rosuvastatin,15 mg rosuvastatin,20 mg rosuvastatin and 40 mg atorvastatin for 12 months(n =80).Low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),total cholesterol,alanine aminotransferase (ALT),aspartate aminotransferase (AST) and creatine kinase(CK) were tested before and 1,12 months after treatment.Carotid intima-media thickness(IMT) and the score of plaques were measured before and 12 months after treatment.Results One month after treatment,levels of LDL-C and total cholesterol in 15 mg rosuvastatin group were significantly lower than those in 10 mg rosuvastatin group and 40 mg atorvastatin group [(2.1 ± 0.4) mmol/L vs (2.4 ± 0.6),(2.3 ± 0.5) mmol/L;(3.3 ± 0.7) mmol/L vs (4.0 ± 0.4),(3.6 ± 0.5) mmol/L];levels of LDL-C and total cholesterol in 15 mg rosuvastatin group were significantly higher than those in 20 mg rosuvastatin group [(1.9 ± 0.5) mmol/L,(3.1 ±0.6)mmol/L] (P ＜ 0.05).Twelve months after treatment,levels of LDL-C and total cholesterol were significantly lower and HDL-C was significantly higher in 15 mg rosuvastatin group than those in 10 mg rosuvastatin group and 40 mg atorvastatin group [(1.8 ± 0.6) mmol/L vs (2.0 ± 0.7),(1.9 ± 0.7) mmol/L;(2.8 ± 0.6) mmol/L vs (3.1 ±0.6),(3.0 ±0.6) mmol/L;(1.01 ±0.27) mmol/L vs (0.82 ±0.32),(0.96 ±0.29) mmol/L];carotid IMT and the score of plaques in 15 mg rosuvastatin group were significantly lower than those in 10 mg rosuvastatin group and 40 mg atorvastatin group[(1.50 ±0.36)mm vs (1.69 ±0.31),(1.61 ±0.31)mm;(2.01 ±0.30) points vs (2.48 ± 0.33),(2.25 ± 0.32) points] (P ＜ 0.01 or P ＜ 0.05);there were no significant differences between 15 mg rosuvastatin group and 20 mg rosuvastatin group (P ＞ 0.05).Rates of ALT/AST increasing ＜ 3 times upper limit of normal value and CK increasing ＜ 5 times upper limit of normal value in 10 mg,15 mg msuvastatin groups and 40 mg atorvastatin group were significantly higher than those in 40 mg atorvastatin group (P ＜ 0.01 or P ＜ 0.05).Conclmions Rosuvastatin 15 mg has intensive lipid-lowering effect that can delay even reveme the progression of carotid plaque.The efficacy of 15 mg rosuvastatin is superior to 40 mg atorvastatin and non-inferior to 20 mg rosuvastatin;the safety is equal to 10 mg rosuvastatin and 40 mg atorvastatin.
Keywords：Cardiovascular diseasesRosuvastatinBlood lipidCarotid plaque
Publication Date：2018-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 341-345 )