Clinical effect of clopidogrel on coronary heart disease patients after drug-eluting stent implantation
Zhang Wei
Lu Shijuan
Zhong Jianghua
Abstract：Objective To investigate the clinical effect of clopidogrel on coronary heart disease patients after drug-eluting stent implantation.Methods Clinical records of 148 patients with stable coronary heart disease who had percutaneous coronary intervention from December 2014 to December 2016 in Haikou People's Hospital were retrospectively analyzed.According to different postoperative antiplatelet treatments,the patients were divided into control group and observation group,with 74 cases in each group.The control group took clopidogrel for 3 months and the observation group took clopidogrel for 6 months after coronary intervention.All patients were followed for 6 months,incidence rates of major adverse events including acute cardiovascular events,rehospitalization,thrombosis and the mortality rate were recorded.Blood lipid and hemorheologic indexes were analyzed before and 6 months after treatment.Results Incidences of acute cardiovascular events,rehospitalization and thrombosis in observation group were significantly lower than those in control group[6.8％ (5/74) vs 14.9％ (11/74),8.1％ (6/74) vs 18.9％ (14/74),4.0％ (3/74) vs 9.5 ％ (7/74)] (P ＜ 0.05).No death occurred in both groups.After 6 months of treatment,levels of total cholesterol,triacylglycerol,low-density lipoprotein cholesterol,low-shear blood viscosity,high-shear blood viscosity,plasma viscosity were significantly lower and high-density lipoprotein cholesterol was significantly higher than those before treatment in both groups [observation group:(1.8 ±0.9)mmol/L vs (4.3 ± 1.0) mmol/L,(0.9 ±0.8) mmol/L vs (1.6 ±0.8)mmol/L,(1.3 ±0.8) mmol/L vs (2.6 ±0.9) mmol/L,(6.8 ±0.6)mPa · s vs (10.8 ±0.7)mPa · s,(4.0 ±0.4)mPa · s vs (6.4 ±0.5)mPa · s,(0.93 ± 0.26) mPa · s vs (1.74 ± 0.31) mPa · s,(1.22 ± 0.24) mmol/L vs (1.02 ± 0.32) mmol/L;control group:(3.6 ±0.9) mmol/L vs (4.2 ± 1.0) mmol/L,(1.3 ±0.8) mmol/L vs (1.6 ± 1.0) mmol/L,(2.0 ±0.8) mmol/L vs (2.6 ±0.9) mmol/L,(8.3 ±0.7)mPa · s vs (10.8 ±0.7)mPa · s,(4.7 ±0.3)mPa · s vs (6.5 ±0.4) mPa · s,(1.24 ± 0.35)mPa · s vs (1.73 ± 0.29)mPa · s,(1.10 ± 0.31)mmol/L vs (0.99 ± 0.27)mmol/L],and there were significant differences between groups (P ＜ 0.05).Conclusion Six months treatment of clopidogrel can effectively improve blood lipid level,hemorheologic indexes and the prognosis in coronary heart disease patients after stent implantation.
Keywords：Coronary atherosclerotic heart diseaseClopidogrelDrug-eluting stent implantation
Publication Date：2018-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 337-340 )