Correlation between thrombomodulin and coronary slow flow

Qin Gang; Jia Yongping; Lyu Jiyuan

doi:10.3760/cma.j.issn.1673-4777.2018.03.003

Abstract：Objective To analyze the correlation between plasma thrombomodulin level and coronary slow flow(CSF).Methods Ninety-four patients with typical/atypical angina pectoris who had coronary angiography from January to December 2016 in First Hospital of Shanxi Medical University were enrolled.Fifty-two patients were diagnosed of CSF by coronary angiography(CSF group) and 42 patiems showed normal coronary flow(control group).Blood indicators,biological indexes and plasma level of thrombomodulin were tested;coronary flow rate was measured by the thrombolysis in myocardial infarction frame count.The correlation between thrombomodulin level and mean TFC was analyzed by Spearman test.Results Plasma level of thrombomodulin in CSF group was significantly higher than that in control group [(4.0 ± 0.3) μg/L vs (3.6 ± 0.3) μg/L] (P ＜ 0.05).There were 42 cases(80.8％) of left anterior descending artery slow flow,11 cases(21.2％) of left circumflex artery slow flow and 29 cases(55.8％) of right coronary artery slow flow in CSF group.Mean TFC of coronary artery in CSF group was significantly higher than that in control group [(36 ± 11) vs (18 ± 6)];corrected TFC of left anterior descending artery,TFC of left circumflex artery and right coronary artery in CSF group were significantly higher than those in control group [(43 ± 12) vs (22 ± 7),(29 ± 8) vs (20 ± 4),(29 ± 4) vs (16 ± 5)] (all P ＜ 0.01).Spearman analysis showed that thrombomodulin level and red blood cell volume distribution width were positively correlated with mean TFC (r =0.323,P =0.002;r =0.231,P =0.016).Multiple linear regression showed that both thrombomodulin level and red blood cell volume distribution width were independent risk factors of CSF(β =0.201,P=0.020;β =0.087,P =0.008).Conclusions Patients with CSF had elevated levels of plasma thrombomodulin.Thrombomodulin may be an independent predictor of CSF.