Effect of hydrochlorothiazide combined with tamsulosin on lower ureteral calculi after extracorporeal shock wave lithotripsy
Song Tianmou
Abstract：Objective To observe the effect of hydrochlorothiazide combined with tamsulosin on lower ureteral calculi after extracorporeal shock wave lithotripsy (ESWL).Methods Totally 120 lower ureteral calculi patients undergoing ESWL from January 2012 to February 2016 in Haian Hospital Affiliated to Nantong University were randomly divided into group A,B,C,with 40 cases in each group.Patients in group A took Niaoshitong pills after operation;group B took Niaoshitong pills plus tamsulosin hydrochloride sustained-release capsules;group C took Niaoshitong pills,tamsulosin hydrochloride sustained-release capsules and hydrochlorothiazide;the course of treatment was 14 d.Stone expelling rate,stone emptying rate,stone expelling time,renal colic attack rate,analgesic drug use rate,steinstrasse formation rate,adverse reactions and complications were analyzed during 3 months follow-up.Results Stone expelling rate and emptying rate in group B and C were significantly higher than those in group A[90.0％ (36/40),95.0％ (38/40) vs 72.5％ (29/40);80.0％ (32/40),87.5％ (35/40) vs 50.0％ (20/40)] (P ＜ 0.05).Stone expelling time,renal colic rate,analgesic drug use rate and steinstrasse formation rate in group B and C were significantly shorter/lower than those in group A[(1.7 ± 0.9),(1.5 ± 0.3)d vs (3.1 ± 1.2) d;27.5％ (11/40) 、7.5％ (3/40) vs 52.5％ (21/40);40.0％ (16/40) 、12.5％ (5/40) vs 70.0％ (28/40);2.5％ (1/40),2.5％ (1/40) vs 12.5％ (5/40)];stone expelling time,renal colic rate and analgesic drug use rate in group C were significantly shorter/lower than those in group B(P ＜0.05).There was no significant difference of adverse reaction rate among groups (P ＞ 0.05).Complication rate in group B and C was significantly lower than that in group A[7.5％ (3/40),2.5％ (1/40) vs 17.5％ (7/40)];complication rate in group C was significantly lower than that in group B (P ＜ 0.05).Conclusion Hydrochlorothiazide combined with tamsulosin treating post-ESWL patients can promote stone expelling,prevent steinstrasse formation,and reduce renal colic attack,use of analgesics and complications.
Keywords：Ureteral calculiExtracorporeal shock wave lithotripsyHydrochlorothiazideTamsulosin
Publication Date：2018-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 253-256 )