Correlation of renal interlobular artery peak systolic velocity and resistance index detected by Doppler ultrasonography with chronic renal insufficiency

Qin Huai; Zhao Chang; Cheng Yi; Zhao Qing; Zheng Ye

doi:10.3760/cma.j.issn.1673-4777.2018.02.021

Abstract：Objective To investigate the correlation of renal interlobular artery peak systolic velocity (PSV) and resistance index (RI) detected by Doppler ultrasonography with chronic renal insufficiency.Methods One hundred and thirty-four in-hospital patients with chronic renal insufficiency admitted in Department of Nephrology,Beijing Anzhen Hospital,Capital Medical University from September 2014 to July 2017 were enrolled as renal insufficiency group,and these patients were divided into group Ⅰ (renal function descent,n =15),group Ⅱ (azotemia,n =101),group Ⅲ (renal failure,n =9) and group Ⅳ (uremia,n =9) according to levels of creatinine and glomerular filtration rate(GFR).Fifty-one patients with normal renal function were enrolled as control group.Renal interlobular artery PSV and RI were measured by color Doppler ultrasonography.Levels of serum creatinine,urea nitrogen,uric acid and urine α1 microglobulin(α1-MG) were tested.Correlations of PSV,RI and the severity of renal insufficiency were analyzed by Pearson analysis.Results Doppler hemodynamic parameters(PSV and RI) and urine biochemical indicators (serum creatinine,urea nitrogen,uric acid and urine α1-MG) showed significant differences among 5 groups(P ＜ 0.05).PSV decreased and RI increased with renal injury severity.PSV in group Ⅱ,Ⅲ,Ⅳ was significantly lower than that in control group[(33 ± 17),(23 ± 10),(23 ±11)cm/s vs (43 ± 17) cm/s];RI in group Ⅰ,]Ⅱ,Ⅲ,Ⅳ was significantly higher than that in control group[(0.63 ±0.06),(0.70±0.07),(0.73±0.09),(0.77±0.09) vs (0.60±0.07)](P＜0.05).Pearson analysis showed that PSV was negatively correlated with the severity of renal insufficiency (r =-0.372,P ＜0.001),and RI was positively correlated with the severity of renal insufficiency (r =0.491,P ＜ 0.001).Conclusions PSV decreases and RI increases with the severity of renal insufficiency.RI is sensitive in early detection of renal impairment.Combined detection of RI and PSV is valuable diagnosis of renal failure.