Diagnostic value of serum pepsinogen combined with gstrin-17 for atrophic gastritis

Su Renchun; Guo Lijun; Wang Junping

doi:10.3760/cma.j.issn.1673-4777.2018.02.020

Abstract：Objective To evaluate the value of serum pepsinogen combined with gstrin-17 in diagnosis of atrophic gastritis.Methods Totally 249 patients with stomach discomfort who visited Shanxi Provincial People's Hospital form March 2016 to May 2017 were included;123 patients were diagnosed of atrophic gastritis by gastroscopy and histopathologic examination,and 126 patients were diagnosed of non-atrophic gastritis.Pepsinogen(PG) and gstrin-17 were tested by enzyme linked immunosorbent assay.Diagnostic values of PG Ⅰ,PG Ⅱ,gstrin-17 and PG Ⅰ/PGⅡ ratio(PGR) were analyzed by the receiver operating characteristic curve and logistics regression.Results Serum levels of PG Ⅰ,PG Ⅱ and gstrin-17 in atrophic gastritis patients were significantly lower than those in non-atrophic gastritis patients[90.050 (65.580,131.930) μg/L vs 158.245 (103.468,228.265) μg/L,9.180 (4.840,16.220) μg/L vs 12.905 (6.120,26.905) μg/L,2.680 (0.680,8.060) pmol/L vs 8.940 (2.603,22.103)pmol/L] (P ＜ 0.05);PGR showed no significant difference between groups (P ＞ 0.05).Sensitivities,specificities,accuracies,positive predictive values and negative predictive values of PG Ⅰ,PG Ⅱ and gstrin-17 in diagnosis of atrophic gastritis were as follows:PG Ⅰ:69.9％,69.0％,69.5％,68.8％,70.2％;PG Ⅱ:66.7％,52.4％,59.4％,57.7％,61.7％;gstrin-17:78.0％,50.0％,63.9％,60.4％,70.0％;PG Ⅰ combined with gstrin-17:60.2％,79.4％,69.9％,74.0％,67.1％;PG Ⅱ combined with gstrin-17:60.2％,70.6％,65.5％,66.7％,64.5％.Logistic regression showed that PG Ⅰ,PG Ⅱ and gstrin-17 had important values in diagnosis of atrophic gastritis(odds ratio =5.185,0.623,2.612).Conclusion Combined detection of serum PG and gstrin-17 is valuable for early diagnosis of atrophic gastritis.