Effect of the operation time of vascular interventional embolization on complication risk and neurologic function in patients with intracranial aneurysm

Zheng Jin; Hu Xuebin; Zhao Hongyang; Zhao Wohua

doi:10.3760/cma.j.issn.1673-4777.2018.02.015

Abstract：Objective To explore the effect of operation time of vascular interventional embolization on complication risk and neurologic function in patients with intracranial aneurysm.Methods Four hundred patients with intracranial aneurysm who had surgical treatments in Department of Neurosurgery,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology from January 2014 to January 2016 were retrospectively analyzed.Two hundred patients were treated by early vascular interventional embolization within 3 d after symptom attack(observation group);200 patients had interventional embolization 3 d after symptom attack(control group).Clinical curative effect,complications,neurologic function [the National Institutes of Health Stroke Scale (NIHSS)] and activities of daily living[the Modified Barthel index(MBI)] were analyzed.Results Complete embolism rate in observation group was significantly higher,most embolism rate and partial embolism rate were significantly lower than those in control group [81.0％ (162/200) vs 56.0％ (112/200),16.0％ (32/200) vs 24.0％ (48/200),3.0％ (6/200) vs 20.0％ (40/200)] (P ＜ 0.05).Postoperative complication rate in observation group was significantly lower than that in control group [0.5％ (1/200) vs 4.5％ (9/200)] (P ＜ 0.05).The NIHSS score and MBI score had no significant differences between groups before operation (P ＞ 0.05).After operation,the NIHSS score was significantly lower and the MBI score was significantly higher than those before operation in observation group and control group [NIHSS:(3.8 ± 1.9) scores vs (19.6 ± 5.2) scores,(9.0 ± 2.0)scores vs (19.7 ±5.2) scores;MBI:(90 ± 10) scores vs (51 ± 10) scores,(75 ± 10) scores vs (51 ± 10) scores],and there were significant differences between groups (P ＜ 0.05).Conclusion Early vascular interventional embolization treating intracranial aneurysm can reduce operation related complications,improve neurologic function and daily living activities.