Effect of continuous blood purification on tumor necrosis factor-α, interleukin-1 and prognosis in patients with acute respiratory distress syndrome
Chen Wei
Abstract：Objective To investigate the effect of continuous blood purification (CBP) on tumor necrosis factor(TNF)-α,interleukin(IL)-1 and prognosis in patients with acute respiratory distress syndrome(ARDS).Methods Thirty-two ARDS patients were enrolled from February 2014 to February 2016 in the First People's Hospital of Lanzhou City;16 of them had CBP therapy for 3-5 d(CBP group) and 16 patients had routine treatments(control group).Serum levels of TNF-α and IL-1 were detected 12,24,36,48,72 h after treatment.Partial pressure of oxygen,partial pressure of carbon dioxide and oxygenation index were measured 2,6,12,24,36,48,72 h after treatment.The fatality rate was analyzed.Results Levels of TNF-α and IL-1 36,48,72 h after treatment in CBP group were significantly lower than those in control group[TNF-α:(36.42 ± 0.41)ng/L vs (49.54 ±0.47) ng/L,(32.79 ± 0.32) ng/L vs (51.36 ± 0.24) ng/L,(29.47 ± 0.58) ng/L vs (56.68 ± 0.21)ng/L;IL-1:(28 ±6) ng/L vs (48 ± 15)ng/L,(25 ±4) ng/L vs (54 ± 10)ng/L,(23 ±3) ng/L vs (80 ± 14) ng/L] (P ＜ 0.05).Partial pressure of oxygen and oxygenation index 24,36,48,72 h after treatment in CBP group were significantly higher,and partial pressure of carbon dioxide was significantly lower than those in control group (P ＜ 0.05).The fatality rate in CBP group was significantly lower than that in control group[18.8％ (3/16) vs 43.8％ (7/16)] (P ＜ 0.05).Conclusion CBP can significantly inhibit expressions of TNF-α and IL-1,improve oxygenation status and reduce the fatality in patients with ARDS.
Keywords：Acute respiratory distress syndromeContinuous blood purificationTumor necrosis factor-αInterleukin-1
Publication Date：2018-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 216-219 )