Effect and safety of targeted light sedation on cardiac surgery patients undergoing perioperative extracorporeal membrane oxygenation
Wang Hong
Li Chenglong
Tian Xiaqiu
Yang Xiaoyu
Du Zhongtao
Jiang Chunjing
Xie Haixiu
Liu Nan
Jia Ming
Hou Xiaotong
Abstract：Objective To investigate the effect and safety of targeted light sedation based on adequate analgesia for perioperative extracorporeal membrane oxygenation(ECMO) supported cardiac surgery patients who had been treated with ECMO for 12-24 h or completed rewarming phase after therapeutic hypothermia.Methods Eightyfour adult cardiac surgery patients who had ECMO during perioperative period were reviewed from January 2016 to December 2016.Seventeen cases who died within 24 h and 17 cases of unconsciousness were excluded,50 cases had targeted light sedation based on the Richmond Agitation-Sedation Scale (RASS) score-2-0.Indicators of effectiveness and safety were analyzed.Results Incidence of agitation or delirium was 26.0％ (13/50).Incidences of renal replacement therapy,infection,lower limb ischemia,ECMO time,intensive care unit stay time and hospital stay time of targeted light sedation were close to those of targeted deep sedation at our center.Patients with agitation or delirium had a higher incidence of serious arrhythmia compared to patients with the RASS score ≤0 and without delirium [69.2％ (9/13) vs 35.1％ (13/37)],the difference was statistically significant (P =0.03).Conclusion Cardiac surgery patients with perioperative ECMO may need deeper sedation,and personalized sedative strategies may be more beneficial.
Keywords：Extracorporeal membrane oxygenationSedationRichmond Agitation-Sedation ScaleSerious arrhythmia
Publication Date：2018-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 191-195 )