Effects of different doses of atorvastatin on postprandial 4 h blood lipid and myocardial revascularization in patients with acute myocardial infarction
Hao Jia
Jiang Shuping
Zhao Jun
Sun Qiang
Zeng Hui
Zhang Shuangyue
Abstract：Objective To analyze the effects of intensive and conventional statin therapy combined with lipid-lowering drugs on postprandial 4 h blood lipid and myocardial revascularization in patients with acute myocardial infarction.Methods A total of 150 acute myocardial infarction patients undergoing selective percutaneous coronary intervention from March 2015 to March 2017 in First Hospital of Qinhuangdao were randomly divided into observation group (75 cases) and control group (75 cases).Based on routine antiplatelet,anticoagulant and heart rate control therapies,patients in observation group took atorvastatin 40 mg and ezetimibe 10 mg,1 time/d;the control group took atorvastatin 20 mg and ezetimibe 10 mg,1 time/d.All patients had echocardiography examination before treatment and 6 months after discharge,and they were tested fasting and postprandial 4 h blood lipid before and 1 week after treatment.Postoperative intensive care unit(ICU) stay time and hospital stay time were recorded.Major adverse cardiovascular events were observed during 6 months of follow-up.Results There were no significant differences of age,sex,histories of diabetes mellitus,hypertension,dyslipidemia,smoking,drinking,angina pectoris,onset to treatment time and Killip cardiac function grade between groups (P ＞ 0.05).Levels of fasting blood lipid and postprandial 4 h blood lipid before treatment had no significant differences between groups (P ＞0.05).One week after treatment,fasting blood lipid in observation group showed no significant difference compared to that in control group;levels of postprandial 4 h total cholesterol,triacylglycerol and low-density lipoprotein cholesterol in observation group were significantly lower,and level of high-density lipoprotein cholesterol was significantly higher than those in control group[(3.87 ± 0.84) mmol/L vs (4.92 ± 0.93) mmol/L,(2.06 ±0.05)mmol/L vs (2.17 ± 0.07) mmol/L,(2.13 ± 0.65) mmol/L vs (2.94 ± 0.61) mmol/L,(1.93 ±0.01) mmol/L vs (1.46 ± 0.01) mmol/L] (P ＜ 0.05).Echocardiogram indexes had no significant differences between groups before treatment(P ＞0.05).After 6 months of follow-up,left ventricular end-diastolic dimension in observation group was significantly lower and left ventricular ejection fraction was significantly higher than those in control group [(4.54 ± 0.11) cm vs (5.43 ± 0.34) cm,(68 ± 6) ％ vs (58 ± 1) ％] (P ＜ 0.05).Postoperative ICU stay time and hospital stay time showed no significant differences between groups (P ＞ 0.05).No adverse cardiovascular events occurred in hospital and during follow-up.Conclusion Compared with conventional dose of statin,intensive statin therapy is more effective in lowering postprandial 4 h blood lipid and promoting heart function recovery after myocardial revascularization in treatment of acute myocardial infarction.
Keywords：Acute myocardial infarctionAtorvastatinLow-density lipoprotein cholesterolHigh-density lipoprotein cholesterolPercutaneous coronary intervention
Publication Date：2018-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 186-190 )