Effect of drug combined with noninvasive mechanical ventilation on refractory heart failure
Wang Ruizhe
Abstract：Objective To investigate the effect of drug combined with noninvasive mechanical ventilation on refractory heart failure.Methods From February 2013 to December 2015,124 cases of intractable heart failure were enrolled in Affiliated Hospital of Shaanxi University of Chinese Medicine,and they were randomly divided into control group and observation group,with 62 cases in each group.The control group was treated by invasive mechanical ventilation,and the observation group was treated by drugs combined with noninvasive mechanical ventilation.Blood gas indexes [arterial partial pressure of oxygen (PaO2),arterial partial pressure of carbon dioxide(PaCO2),arterial oxygen saturation (SaO2),respiratory rate,heart rate],hemodynamic indexes [extravascular lung water index (EVLWI),global end-diastolic volume index (GEDVI),intrathoracic blood volume index (ITBVI),cardiac function index (CFI)],laboratory indexes [B-type brain natriuretic peptide (BNP),cardiac troponin T(cTnT),lactic acid] and the clinical curative effect were analyzed.Results There were no significant differences of blood gas,hemodynamic and laboratory indexes between groups before ventilation (P ＞ 0.05).Mter 3 h ventilation,PaO2 and GEDVI in observation group were significantly higher than those in control group[(60 ± 4) mmHg vs (58 ± 4) mmHg,(821 ± 23) rnl/m2 vs (790 ± 26) ml/m2];respiratory rate,heart rate,CFI,BNP and lactic acid in observation group were significantly lower than those in control group [(26.5 ± 2.1) times/min vs (28.2 ± 2.4) times/min,(110 ± 3) times/min vs (110 ± 5) times/min,(4.0 ±1.4)L/minvs (4.5±1.2)L/min,(1 573 ±177)pmol/Lvs (2 033 ±157)pmol/L,(3.7±1.9)mmol/Lvs (4.7 ± 1.6)mmol/L] (all P ＜0.01).After 24 h ventilation,PaO2,PaCO2,SaO2,EVLWI,GEDVI and ITBVI in observation group were significantly higher than those in control group;respiratory rate,heart rate,CFI,BNP,cTnT and lactic acid in observation group were significantly lower than those in control group(all P ＜0.05).The total effective rate in observation group was significantly higher than that in control group [95.2％ (59/62) vs 74.2％ (46/62)] (x2 =10.695,P =0.013).Conclusion Drug combined with noninvasive mechanical ventilation treating refractory heart failure can significantly improve breathing and ventilation function.
Keywords：Refractory heart failureDrug therapyNoninvasive mechanical ventilation
Publication Date：2018-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 177-181 )