Effect of salvianolic acid on cardiac function and renal hemodynamics in heart failure rats
Qiu Qi
Cao Jinglin
Wei Yun
Lu Linghui
Hao Xiaoyan
Wang Zhisheng
Wang Yong
Lin Yang
Abstract：Objective To investigate the effect of salvianolic acid on cardiac function and renal hemodynamics in heart failure rats.Methods Twenty-five clean grade male SD rats were randomly divided into sham operation group(5 rats) and model group(20 rats);15 rats were randomly divided into model control group,fosinopril sodium group and salvianolic acid group,with 5 rats in each group.Heart failure rat models were prepared by left anterior descending coronary ligation.Medical treatments were started on the 4th day after operation,2 times/d in the morning and before bedtime.After 60 d of treatments,left ventricular end-diastolic diameter (LVEDD),left ventricular end-systolic dimension (LVEDS),ejection fraction (EF) and fractional shortening (FS) measured by echocardiogram,and blood flow systolic peak velocity,diastolic peak velocity,resistance index and accelerated speed of intrarenal arteries (main artery of renal hilum,segmental artery,interlobar artery) mensurated by color Doppler were analyzed.Results After 60 d of drug treatment,LVEDS in model control group was significantly higher,and EF and FS were significantly lower than those in sham operation group [(6.16 ±2.12)mmvs(3.60±0.25)mm,(37 ±18)％ vs(65 ±6)％,(22 ±11)％ vs(38 ±4)％] (P＜0.01);LVEDD,LVEDS,EF and FS had no significant differences among model control group,fosinopril sodium group and salvianolic acid group(P ＞ 0.05).Blood flow accelerated speeds of renal segmental artery and interlobar artery in model control group were significantly lower than those in sham operation group[(6 518 ± 2 870)mm/s2 vs (16 830 ± 3 255)mm/s2,(5 511 ± 1 275)mm/s2 vs(17 647 ± 3 887)mrm/s2] (P ＜ 0.01);systolic and diastolic peak velocities of segmental artery in salvianolic acid group were significantly higher than those in model control group[(279 ± 102) mm/s vs(158 ±37) mm/s,(138 ±61)mm/s vs (77 ± 19)mm/s] (P ＜0.05);there were no significant differences of other renal hemodynamic indexes among model control group,fosinopril sodium group and salvianolic acid group (P ＞ 0.05).Conclusion Salvianolic acid shows no positive effect on cardiac function but it can improve renal hemodynamic state in heart failure rats.
Keywords：Heart failureSalvianolic acidHeart functionRenal hemodynamics
Publication Date：2018-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 173-176 )