Clinical effect of levornidazole sodium chloride injection on patients after cholecysto-choledocholithiasis surgery

Zhao Xupeng; Guo Dawei; Li Zhen; Yang Keyu; Chu Chen; Xie Qiang; Zhou Yong

doi:10.3760/cma.j.issn.1673-4777.2018.01.023

Abstract：Objective To evaluate the effect of levornidazole sodium chloride injection on patients after surgery of cholecystolithiasis complicated with choledocholithiasis (CCWC).Methods Clinical data of 120 patients with CCWC who had laparoscopic cholecystectomy combined with common bile duct exploration from August 2015 to June 2017 in the Fourth Affiliated Hospital of China Medical University were retrospectively analyzed;bile was extracted during operation for bacterial culture.The observation group(60 cases) had intravenous administration of the 3rd generation cephalosporins plus levornidazole sodium chloride injection and the control group(60 cases) had intravenous administration of the 3rd generation cephalosporins plus ornidazole sodium chloride injection after operation;0.5 g/time,2 times/d,lasting for 3 d.Clinical efficacy,bacteriological efficacy and incidence of adverse reactions were analyzed.Results Normal ratios of leukocyte count and neutrophil percentage in observation group were significantly higher than those in control group after treatment[95.0％ (57/60) vs 81.7％ (49/60),90.0％ (54/60) vs 75.0％ (45/60)] (P ＜ 0.05).Positive rate of anaerobic infection showed no significant difference between groups (P ＞ 0.05).After medication,.clearance rate in observation group was higher than that in control group but the difference was not significant (P ＞ 0.05).Incidences of dizziness and drowsiness in observation group were significantly lower than those in control group[0.0％ (0/60) vs 13.3％ (8/60),0.0％ (0/60) vs 6.7％ (4/60)] (P ＜ 0.05).Conclusion Application of levomidazole sodium chloride injection can help promote recovery of patients with CCWC surgery with less adverse reaction.