Efficacy and safety of metformin hydrochloride sustained release tablets and common metformin hydrochloride tablets in treatment of type 2 diabetes mellitus
Jiang Aifeng
Ma Liping
Wang Yixin
Feng Yan
Zhang Peixue
Zhang Miaomiao
Abstract：Objective To analyze the efficacy and safety of metformin hydrochloride sustained release tablets and common metformin hydrochloride tablets in treatment of type 2 diabetes mellitus.Methods Totally 120 patients with type 2 diabetes mellitus were enrolled from January 2013 to January 2017 in Beijing Anzhen Hospital,Capital Medical University;they were divided into observation group and control group,with 60 cases in each group.The observation group took metformin hydrochloride sustained release tablets 1 500 mg/time,1 time/d;the control group took common metformin hydrochloride tablets 500 mag/time,3 times/d;both groups were treated for 3 months.Blood glucose indexes,clinical efficiency and adverse reactions were analyzed.Results Fasting plasma glucose (FPG),postprandial 2 h plasma glucose (2 h PG) and glycosylated hemoglobin (HbA1 c) after treatment were significantly lower than those before treatment[observation group:(5.30 ± 0.21)mmol/L vs (8.21 ± 0.43)mmol/L,(6.7± 1.0)mmol/L vs (11.5 ±1.3)mmol/L,(6.0 ±1.2)％ vs (8.5 ±1.4)％;control group:(5.31 ± 0.22) mmol/L vs (8.22 ±0.43) mmol/L,(6.7 ± 1.0) mmol/L vs (11.5 ± 1.3) mmol/L,(6.1 ± 1.2)％ vs (8.5 ± 1.4)％] (P ＜0.05);there were no significant differences of FPG,2 h PG and HbA1c between groups(P ＞0.05).The total effective rate in observation group was higher than that in control group[93.3％ (56/60) vs 90.0％ (54/60)] (P ＞ 0.05).There was no significant differences of incidences of diarrhea,epigastric pain,vomiting and indigestion between groups(P ＞0.05).Conclusion Metformin hydrochloride sustained release tablets and common metformin hydrochloride tablets are both safe and effective in treatment of type 2 diabetes.
Keywords：Diabetes mellitustype 2Metformin hydrochloride sustained-release tabletsMetformin hydrochloride tablets
Publication Date：2018-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 66-69 )