Effect of dl-3n-butyphthalide on early neurological function in patients with acute middle cerebral occlusion
Liu Xuanjun
Yang Guoshuai
Lin Haili
Hu Yujie
Zhou Yanhui
Cheng Qihui
Lin Zhuxin
Zhou Lü
Abstract：Objective To investigate the effect of dl-3n-butyphthalide (NBP) on early neurological function in patients with middle cerebral artery occlusion (MCAO).Methods Sixty-nine patients with acute MCAO were enrolled from March 2015 to March 2017 in Affiliated Haikou Hospital of Xiangya School of Medicine,Central South University;they were randomly divided into control group (35 cases) and NBP group (34 cases).Both groups had routine treatment for MCAO and the NBP group took NBP capsules 0.2 g/time,3 times/d for 14 d.Score of the National Institutes of Health Stroke Scale (NIHSS) was recorded before and 14 d after treatment;cerebral collateral circulation was assessed by transcranial Doppler;the 14 d mortality was calculated;score of the modified Rankin Scale(mRS) was recorded after 90 d follow-up.Results Finally 30 cases in control group and 30 cases in NBP group were analyzed.The NIHSS score in NBP group 14 d after treatment was significantly lower than that before treatment and that in contro l group [(7.9 ± 1.3) points vs (11.5 ± 1.3),(9.6 ± 1.7)points];cerebral collateral circulation 14 d after treatment in NBP group significantly increased than that before treatment and that in control group (P ＜ 0.05).The 14 d mortality rate had no significant difference between groups(P ＞0.05).The 90 d mRS score in NBP group was significantly lower than that in control group (P ＜ 0.05).Conclusion Early administration of NBP can help improve neurological function in patients with acute MCAO.
Keywords：Acute middle cerebral artery occlusionDl-3n-butyphthalideNeurological function
Publication Date：2018-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 59-62 )