Clinical features of pertussis infection and non-pertussis infection in children with chronic cough
Zhang Xiaofang
Liu Xiaoguai
Li Ruina
Guo Chunyan
Fu Jia
Abstract：Objective To compare clinical features of pertussis infection and non-pertussis infection in children with chronic cough.Methods Clinical data of 189 children with chronic cough who were admitted from June 2013 to June 2017 in Xi'an Children's Hospital were retrospectively analyzed.Diagnosis of pertussis infection was defined as pertussis toxin immunoglobulin G ＞ 100 kU/L;the children were divided into pertussis group (40 cases) and non-pertussis group (149 cases).Clinical characteristics,laboratory indicators and imaging findings were analyzed.Results Sex,age,registered permanent residence,immunization of pertussis vaccine and length of cough had no significant differences between groups(P ＞ 0.05).Incidences of lymphocyte abnormality,leukocyte abnormality,fever,paroxysmal cough,expectoration,cyanosis,echoes,short of breath had no significant differences between groups(P ＞ 0.05).Incidences of conjunctival bleeding,pneumonia and asphyxia in pertussis group were significantly higher than those in non-pertussis group[20.0％ (8/40) vs 2.7％ (4/149),100.0％(40/40) vs 75.2％ (112/149),15.0％ (6/40) vs 2.7％ (4/14)] (P ＜0.01).Logistic regression analysis showed that conjunctival bleeding,pneumonia and asphyxia were independent features of pertussis infection in children with chronic cough (P ＜ 0.01).Conclusion Pertussis infection is one of important causes of chronic cough in children;conjunctival bleeding,pneumonia and asphyxia may be independent features of oertussis infection in differential diagnosis of chronic cough with or without pertussis infection.
Keywords：Chronic coughWhooping coughInfectionClinical features
Publication Date：2018-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 51-54 )