Clinical research on dexmedetomidine caudal analgesia in children with congenital heart disease surgery
Li Weimin
Zhong Jiying
Li Yanxue
He Xinmin
Abstract：Objective To investigate the effectiveness and safety of dexmedetomidine caudal analgesia in children with congenital heart disease surgery.Methods Seventy children undergoing elective atrial/ventricular septal defect repair(American Society of Anesthesiologists Ⅰ-Ⅱ) from May 2016 to April 2017 in Foshan First People's Hospital were randomly divided into dexmedetomidine group and morphine group,with 35 cases in each group.Patients in dexmedetomidine group and morphine group were respectively treated by caudal analgesia with dexmedetomidine 1 μg/kg and morphine 100 μg/kg after basal anesthesia;all patients had nurse-controlled intravenous analgesia after operation.The Face,Legs,Activity,Cry,Consolability(FLACC) score and the Ramsay sedation score were assessed 1 h(T1),4 h(T2),8 h(T3),12 h(T4),24 h(T5),48 h(T6) after operation.Sufentanil consumption,demand times of intravenous analgesia and occurrence of adverse reactions in 24,48 h after operation were analyzed.Results The FLACC score showed no significant difference between groups (P =0.26).The Ramsay sedation scores at T1,T2,T3 in morphine group were significantly higher than those in dexmedetomidine group [3 (2,3) points vs 2 (1,3) points,4 (3,5) points vs 3 (2,3) points,3 (3,4) points vs 2(2,3)points] (P ＜ 0.05);the Ramsay sedation scores at T4,T5,T6 had no significant differences between groups(P ＞0.05).Sufentanil consumption and demand times of effective intravenous analgesia had no significant differences between groups(P ＞ 0.05).Demand times of ineffective intravenous analgesia in 24,48 h after operation in dexmedetomidine group were significantly more than those in morphine group [2 (0,3) times vs 0 (0,1) times,2 (0,3) times vs 1 (0,1) times] (P ＜ 0.05).There was no serious adverse reaction in both groups.Incidences of nausea and vomiting and total incidence of adverse reactions in dexmedetomidine group were significantly lower than those in morphine group[8.6％ (3/35) vs 17.1％ (6/35),8.6％ (3/35) vs 31.4％ (11/35)] (P ＜0.05).Conclusion Dexmedetomidine caudal analgesia is effective in children with congenital heart disease surgery;it may not reduce the use of sufentanil but can reduce adverse reaction,and improve security.
Keywords：Congenital heart disease surgeryDexmedetomidineCaudal analgesia
Publication Date：2018-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 39-43 )