Effectiveness and safety of low dose unfractionated heparin combined with sequential enoxaparin on diabetic patients undergoing elective percutaneous coronary intervention
Hou Xuejian
Li Zhizhong
Wang Su
Cheng Yutong
Sun Tao
Huang Ji
Abstract：Objective To explore the effectiveness and safety of low dose unfractionated heparin (UFH) combined with sequential enoxaparin on diabetic patients undergoing elective percutaneous coronary intervention (PCI).Methods A total of 490 diabetic patients who were diagnosed of stable or unstable angina undergoing PCI from June 2015 to June 2016 in the 5th Department of Cardiology,Beijing Anzhen Hospital,Capital Medical University were randomly assigned to have UFH with sequential enoxaparin (experimental group,n =249) and routine UFH(control group,n =241).Patients in both groups were administered 3 000 U UFH before coronary angiography;the experimental group was administered enoxaparin 0.75 mg/kg and the control group was added UFH to a total dose of 100 U/kg before PCI.Incidences of major adverse cardiac events (MACE) including all-cause mortality,recurrent myocardial infarction and target vessel revascularization in 30 d and 1 year after PCI were analyzed.Results No MACE occurred in 30 d and 1 year after PCI in both groups.The 30 d and 1 year recurrent angina and rehospitalization rates had no significant differences between experimental group and control group [2.8％ (7/249) vs 2.1 (5/241),11.6％ (29/249) vs 9.1％ (22/241)] (P ＞ 0.05),and the recurrent angina and rehospitalization rate showed no significant difference between groups in further analysis based on confounding factors adjustment (odds ratio =1.32,95％ confidence interval:0.75-2.30,P =0.33).Conclusion UFH with sequential enoxaparin may be as effective and safe as the standard UFH anticoagulant therapy in elective PCI for diabetic patients with stable or unstable angina.
Keywords：Diabetes mellitusPercutaneous coronary interventionUnfractionated heparinEnoxaparin
Publication Date：2018-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 31-35 )