Effect of trimetazidine on left ventricular function and exercise tolerance in acute ST-elevation myocardial infarction patients after emergency percutaneous coronary intervention
Zhan Xiaona
Li Guihua
Wang Yajuan
Gao Lei
Fu Lijuan
Abstract：Objective To investigate the effect of trimetazidine on left ventricular function and exercise tolerance in acute ST-elevation myocardial infarction (STEMI) patients after emergency percutaneous coronary intervention(PCI).Methods A total of 187 STEMI patients who had emergency PCI from March 2012 to February 2015 in Beijing Chuiyangliu Hospital were randomly divided into control group(94 cases) and trimetazidine group (93 cases).Both groups were treated with conventional therapy after PCI;the trimetazidine group took trimetazidine since 2 weeks after PCI.Occurrences of angina pectoris and major adverse cardiac events (MACE) were observed during 12 months of follow-up.Left ventricular ejection fraction (LVEF) and 6-min walk distance were recorded 2 weeks and 3,6,12 months after PCI.Results Finally 85 cases in control group(9 cases lost to follow-up) and 83 cases in trimetazidine group(6 cases lost to follow-up,1 case had gastrointestinal reaction and withdrew from the trail,3 cases stopped taking drugs) were analyzed.The 12-month angina pectoris rate in trimetazidine group was significantly lower than that in control group [7.2％ (6/83) vs 17.6％ (15/85)] (P ＜ 0.05).The MACE rate had no significant difference between groups(P ＞0.05).LVEF and 6-min walk distance had no significant differences between groups 2 weeks and 3 months after PCI(P ＞ 0.05).LVEF and 6-min walk distance 6,12 months after PCI in trimetazidine group were significantly higher(longer) than those in control group (P ＜ 0.01).Conclusion Post-PCI use of trimetazidine in ST-elevation myocardial infarction patients helps improve heart function and increase exercise tolerance.
Keywords：Acute ST-elevation myocardial infarctionTrimetazidineEmergency percutaneous coronary interventionExercise tolerance
Publication Date：2018-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 21-23 )