Weight-loss and lipid-lowering effects of nostoc commune powder on rats
Ma Yage
Zhang Xi
Zhao Shenglan
Zhu Youyuan
Abstract：Objective To explore the weight-loss and lipid-lowering effects of nostoc commune powder on rats with nutritional obesity.Methods Nutritional obese SD rats (4 weeks old,specific pathogen free) were divided into blank control group,model control group,simvastatin group,metformin group and high,medium,low doses of nostoc commune powder groups.The blank control group had normal diet;other groups had high-fat diet and corresponding medical treatments (once daily for 8 weeks).Body mass,organ index,serum levels of total cholesterol(TC),triacylglycerol(TG),high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol(LDL-C) were analyzed after 8 weeks of treatment.Results After treatment,body mass in model control group was significantly higher than that in blank control group[(524 ± 37)g vs (473 ± 44)g] (P ＜ 0.05);body mass in metformin group,simvastatin group and high,medium,low doses of nostoc commune powder groups [(486 ± 40),(506 ± 34),(444 ± 47),(447 ± 30),(456 ± 27) g] was significantly lower than that in model control group (P ＜ 0.05).Liver index in simvastatin group and high,medium,low doses of nostoc commune powder groups was significantly lower than that in model control group(P ＜0.05).Renal index had no significant differences between model control group and other groups (P ＞ 0.05).Spleen index in simvastatin group and high dose nostoc commune powder group was significantly higher than that in model control group(P ＜ 0.01).TC and TG in high,medium,low doses of nostoc commune powder groups were significantly lower and LDL-C was significantly higher than those in model control group(P ＜ 0.05).HDL-C in medium and low doses of nostoc commune powder groups was significantly lower than that in model control group(P ＜ 0.05).Conclusion Nostoc commune powder can reduce body weight,serum TC,TG and alleviate liver enlargement in rats with nutritional obesity;it has no obvious effect on kidney but may have some injury on spleen.
Keywords：HypolipidemicNutritional obese ratsNostoc communeAnti-obesity
Publication Date：2017-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1835-1839 )