Effect of urapidil combined with nimodipine on serum creatinine, calcium and safety in hypertensive patients with cerebral hemorrhage
Zhou Feng
Ma Li
Lu Guojian
Fu Guoping
Dong Fen
Abstract：Objective To investigate the effect of urapidil combined with nimodipine on serum creatinine,calcium and safety in hypertensive patients with cerebral hemorrhage.Methods A total of 44 hypertensive patients with cerebral hemorrhage admitted from June 2014 to June 2016 in Shaoxing Second Hospital were randomly divided into observation group and control group,with 72 cases in each group.Both groups had routine symptomatic supportive treatments and intravenous injection of urapidil hydrochloride;the observation group took nimodipine additionally.After 15 d of treatment,serum levels of creatinine and calcium,volume of cerebral hematoma,score of the National Institutes of Health Stroke Scale(NIHSS) and adverse reactions were analyzed.Survival condition of patients was recorded in 1 year after treatment.Results Serum levels of creatinine and calcium,volume of cerebral hematoma and the NIHSS score had no significant differences between groups before treatment (P ＞ 0.05).After treatment,serum creatinine level was significantly lower,serum calcium level was significantly higher,cerebral hematoma volume and the NIHSS score were significantly less in observation group than those in control group[(65 ±7) μ mol/L vs (76 ±6) μ mol/L,(2.55 ±0.25) mmol/L vs (2.13 ±0.42) mmol/L,(3.0 ± 1.2) mm3 vs (5.1 ± 1.4) mm3,(7.8 ± 2.7) points vs (9.6 ± 2.1) points] (P ＜ 0.01).Incidence of adverse reactions had no significant difference between groups [12.5％ (9/72) vs 18.1％ (13/72)] (P =0.61).The 1 year survival rate in observation group was significantly higher than that in control group [93.1％ (67/72) vs 83.3％ (60/72)] (P =0.03).Kaplan-Meier survival curve showed that the survival time in observation group was significantly longer than that in control group (P ＜ 0.001).Conclusion Urapidil combined with nimodipine treating hypertension complicated by cerebral hemorrhage can effectively increase serum calcium,reduce serum creatinine,diminish cerebral hematoma and improve neurologic function without significant adverse effects.
Keywords：HypertensionCerebral hemorrhageNimodipine
Publication Date：2017-12-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1814-1817 )