Clinicopathological analysis of primary cardiac rhabdomyoma in 26 fetuses and infants
Zhu Qing
He Chenyu
Shang Jianfeng
Chen Dong
Abstract：Objective To investigate clinicopathological features,diagnosis and differential diagnosis of primary cardiac rhabdomyoma.Methods Twenty-six cases of cardiac rhabdomyoma of fetal autopsy and infant surgical resection were analyzed through general visual observation,hematoxylin-eosin staining and immunohistochemical staining at Department of Pathology,Beijing Anzhen Hospital,Capital Medical University from 2010 to 2017.Results In 24 cases of fetal autopsy,7 cases(29.2％) had single tumor,17 cases(70.8％) had multiple tumors;11 cases(45.8％) had rhabdomyoma in left ventricle,2 cases(8.3％) had rhabdomyoma in right ventricle,11 cases (45.8％) had tumors in both side;2 cases(8.3％) with brain nodules were diagnosed of tuberous sclerosis complex;10 cases(41.7％) had septal tumor.Two samples of surgical resection came from a 5 months old infant and an 1 month old infant;the 5 months old infant had a tumor nodule in pulmonary artery and right ventricular outflow tract.Hematoxylin-eosin staining showed eosinophilic or vacuolar cells,small to medium nucleus with obvious nucleolus;there were spider-like cells but no mitotic figure was observed.Immunohistochemical staining showeddesmin(+),myoglobin(+),vimentin(+),Ki-67(1％),S-100(-),CD31(-),CD34(-),myogenic differentiation 1 (-),myosin(-),smooth muscle actin(-).Conclusions Cardiac rhabdomyoma is common in fetus and infant;it can be diagnosed by echocardiography during gestation period;the complication of tuberous sclerosis complex is rare.Immunohistochemical test and genetic test are useful in diagnosis of cardiac rhabdomyoma.
Keywords：Congenital heart diseaseCardiac rhabdomyomaTuberous sclerosisPathology
Publication Date：2017-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1805-1808 )