Clinical effect of selenium yeast combined with levothyroxine sodium on type 2 diabetes complicated with chronic lymphocytic thyroiditis

Zhang Cheng; Zeng Fei; Liu Xiaoping; Yang Yali; Li Hong; Kang Chuanzhe

doi:10.3760/cma.j.issn.1673-4777.2017.11.019

Abstract：Objective To observe the clinical effect of selenium yeast combined with levothyroxine sodium on type 2 diabetes complicated with chronic lymphocytic thyroiditis (CLT).Methods Totally 78 type 2 diabetic patients with CLT from June 2015 to November 2016 in the 452 Hospital of the Chinese People's Liberation Army were randomly divided into group A and group B,with 39 cases in each group.Group A took levothyroxine sodium tablets based on basic hypoglycemic therapies;group B took selenious yeast tablets in addition.Blood glucose,thyroid function indexes,clinical efficacy and adverse reactions were analyzed.Results Levels of fasting blood glucose,postprandial 2 h blood glucose,glycosylated hemoglobin,thyroid peroxidase antibody and thyroglobulin antibody after treatment in group B were significantly lower than those in group A [(5.00 ± 0.10) mmol/L vs (5.60±0.30)mmol/L,(8.50 ±0.40)mmol/L vs (10.60 ± 0.40) mmol/L,(4.70 ±0.20)％ vs (5.80±0.13) ％,(119 ± 19) mU/L vs (290 ± 31) mU/L,(87 ± 19) mU/L vs (172 ± 22) mU/L];levels of fasting C peptide and postprandial 2 h C peptide after treatment in group B were significantly higher than those in group A [(2.06 ± 0.21) μg/L vs (1.27 ± 0.22) μg/L,(5.27 ± 0.43) μg/L vs (2.63 ± 0.26) μg/L] (all P ＜ 0.05).The total effective rate in group B was significantly higher than that in group A[94.9％ (37/39) vs 69.2％ (27/39)] (P ＜ 0.05).After treatment,improvement rate of clinical symptoms (thyroid pain,swelling and myxedema) in group B was significantly higher than that in group A(P ＜ 0.05).The incidence rate of adverse reactions in group B was significantly lower than that in group A[0.0％(0/39) vs 10.3％(4/39)](P＜0.05).Conclusion Selenium yeast combined with levothyroxine sodium treating type 2 diabetes with CLT is effective in relieving symptoms,reducing adverse reactions and improving life quality.