Relation between peripheral vascular disease and serum 25-hydroxyvitamin D3 in patients with type 2 diabetes mellitus
Nong Xiting
Cheng Shuying
Li Nan
Zhao Jie
Abstract：Objective To analyze the relation between peripheral vascular disease and serum 25-hydroxyvitamin D3 [25-(OH) D3] in patients with type 2 diabetes mellitus (T2 DM).Methods One hundred and eighty-six patients with T2DM who were hospitalized in Xi'an Central Hospital from October 2014 to October 2016 were enrolled as T2DM group,they were divided into peripheral vascular disease group(86 cases) and non-complication group(100 cases);80 healthy people were enrolled as normal control group.According to serum level of 25-(OH) D3,186 diabetic patients were divided into group A(4.0-12.0 μg/L),group B(12.1-18.0 μg/L) and group C(18.1-24.0 μg/L),with 62 cases in each group.Influence factors of peripheral vascular disease were analyzed by multivariate logistic regression.The relation between 25-(OH) D3 and peripheral vascular disease was analyzed by Pearson correlation analysis.Results Age,waist-to-hip ratio,systolic blood pressure,diastolic blood pressure,total cholesterol,triacylglycerol,low-density lipoprotein cholesterol(LDL-C),glycosylated hemoglobin (HbA1c) level and smoking ratio in T2 DM group were significantly higher and high-density lipoprotein cholesterol (HDL-C),25-(OH)D3 level were significantly shorter (lower) than those in normal control group(P ＜0.05).Male ratio,drinking ratio and body mass index had no significant differences between T2DM group and normal control group (P ＞ 0.05).Age,body mass index,systolic blood pressure,diastolic blood pressure,total cholesterol,LDL-C,HbA1 c level and smoking ratio in peripheral vascular disease group were significantly higher and course of disease,25-(OH) D3 level were significantly lower than those in non-complication group (P ＜ 0.05).Male ratio,drinking ratio,waist-to-hip ratio,triacylglycerol and HDL-C level had no significant differences between peripheral vascular disease group and non-complication group (P ＞ 0.05).Logistic regression analysis showed that age,course of disease,smoking,systolic blood pressure,LDL-C and HbA1c were risk factors and 25-(OH) D3 was an protective factor of peripheral vascular disease (P ＜ 0.05).Pearson analysis showed that 25-(OH) D3 was negatively correlated with the incidence of peripheral vascular disease (group A:odds ratio =1.447,95％ confidence interval:1.022-2.225,P =0.009;group B:odds ratio =1.215,95％ confidence interval:1.085-1.852,P =0.024;group C:odds ratio =1.112,95％ confidence interval:1.103-1.675,P =0.039).Conclusions Serum level of 25-(OH) D3 is negatively correlated with occurrence of peripheral vascular disease in T2DM patients.Serum level of 25-(OH) D3 is a protective factor of peripheral vascular disease.
Keywords：Diabetes mellitustype 2Peripheral vascular disease25-hydroxy vitamin D3
Publication Date：2017-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1668-1672 )