Effect of insulin pump intensive treatment on glycolipid metabolism, islet function, inflammatory factors and oxidative stress in newly diagnosed type 2 diabetic patients
Gu Guangyu
Abstract：Objective To analyze the effect of insulin pump intensive treatment on glycolipid metabolism,islet function,inflammatory factors and oxidative stress in newly diagnosed type 2 diabetic patients.Methods One hundred patients newly diagnosed of type 2 diabetes from January 2016 to April 2017 in the Second Hospital of Tianjin Medical University were randomly divided into observation group and control group with 50 cases in each group.The observation group had continuous subcutaneous insulin infusion by insulin pump;the control group had multiple subcutaneous injections of insulin.After 2 weeks of treatment,blood glucose,blood lipid,islet function,inflammatory factors and oxidative stress indexes were analyzed.Results There were no differences of laboratory indexes between groups before treatment(P ＞ 0.05).Fasting blood glucose,postprandial 2 h blood glucose and glycosylated hemoglobin had no differences between groups after treatment (P ＞ 0.05).After treatment,total cholesterol,triacylglycerol,low-density lipoprotein cholesterol,insulin resistant index,high-sensitive C-reactive protein,intedeukin-6,tumor necrosis factor-α and malondialdehyde significantly decreased;high-density lipoprotein cholesterol,fasting insulin,fasting C-peptide,insulin secretion index,glutathione peroxidase and superoxide dismutase significantly increased;there were significant differences of these indexes between observation group and control group [(4.3 ± 1.0) mmol/L vs (4.7 ± 1.0) mmol/L,(1.6 ± 0.7) mmol/L vs (1.8 ± 0.8) mmol/L,(2.5±0.7)mmol/L vs (2.6±0.7)mmol/L,(3.3 ±0.9) vs (4.2 ±1.0),(1.3 ±1.0)mg/L vs (2.0±1.2)mg/L,(7.3±1.7)ng/L vs (8.9 ±1.6)ng/L,(0.86 ±0.20)ng/L vs (1.15 ±0.27)ng/L,(2.3 ±0.7) μmoL/L vs (3.2 ± 0.8) μmol/L,(2.0 ± 1.0) mmol/L vs (2.0 ± 1.0) mmol/L,(23.7 ± 1.3) mU/L vs (17.8 ±2.0)mU/L,(1.89 ±0.38)μg/L vs (1.42 ± 0.29) μg/L,(99±21) vs (82±18),(186 ±20)U/L vs (162 ±28)U/L,(37 ± 10)U/L vs (33 ±9)U/L]] (P ＜0.05).Conclusion Continuous subcutaneous insulin infusion by insulin pump treating newly diagnosed type 2 diabetes can effectively control blood glucose,regulate lipid metabolism,reduce insulin resistance,improve islet function,reduce inflammation factors and suppress oxidative stress.
Keywords：Diabetes mellitus,type 2Insulin pumpIslet functionInflammation factorsOxidative stress
Publication Date：2017-11-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1660-1664 )