Clinical effect of mecobalamin on post-stroke depression in senile patients with cerebral infarction accompanied by hyperhomocysteinemia

Liu Huahui

doi:10.3760/cma.j.issn.1673-4777.2017.11.014

Abstract：Objective To analyze the effect of mecobalamin on plasma level of homocysteine (Hcy) and quality of life in post-stroke depressive senile patients with hyperhomocysteinemia.Methods Totally 103 senile patients with post-stroke depression accompanied by hyperhomocysteinemia from February 2015 to February 2017 in the First Affiliated Hospital of Guangxi Medical University were randomly divided into control group(n =51) and observation group (n =52).The control group had routine therapy;the observation group was treated with mecobalamin on the basis of conventional therapy.After 14 d of treatment,clinical effective rate,plasma level of Hcy,scores of the Symptom Checklist (interpersonal relationship,anxiety,depression,somatization,terror and other factors),adverse reaction rate and score of the Greneric Quarity of Life Inventor (GQOLI) were analyzed.Results The total effective rate in observation group was significantly higher than that in control group [86.5％(45/52) vs 66.7％ (34/51)] (P ＜0.05).Plasma level of Hcy after treatment in observation group was significantly lower than that in control group[(15.8 ± 3.0) μmol/L vs (20.4 ± 2.2) μmol/L] (P ＜ 0.05).Scores of interpersonal relationship,somatization,anxiety,depression,terror and other factors after treatment in observation group were significantly higher than those in control group(P ＜0.05).The adverse reaction rate had no significant difference between groups(P ＞ 0.05).The GQOLI score in observation group was significantly higher than that in control group[(220 ± 11) scores vs (188 ± 10) scores] (P ＜ 0.05).Conclusion Mecobalamin treating post-stroke depression in senile patients with cerebral infarction accompanied by hyperhomocysteinemia is safe and effective in lowering plasma Hcy level and improving patients' psychological status and quality of life.