Clinical effect of high dose rabeprazole on acute severe craniocerebral injury complicated with upper gastrointestinal hemorrhage
Huang Tianzao
Abstract：Objective To investigate the clinical effect of high dose rabeprazole on acute severe craniocerebral injury complicated with upper gastrointestinal hemorrhage.Methods Forty-two patients with acute severe craniocerebral injury complicated with upper gastrointestinal hemorrhage from June 2015 to December 2016 in Fujian Medical University 2nd Affiliated Hospital were randomly divided into control group and observation group,with 21 cases in each group.The observation group was treated by intravenous drip of high dose of rabeprazole;the control group had routine dose of intravenous rabeprazole;both groups were treated for 5 d.Gastric juice pH value was tested 4,12,24 h after treatment;blood routine and biochemical indicators were tested 24,48 h after treatment;clinical efficacy and adverse reactions were analyzed.Results The 4,12,24 h gastric juice pH values in observation group were significantly higher than those in control group [(4.08 ± 0.15) vs (3.15 ± 0.27),(5.66 ± 0.45) vs (3.67 ± 0.51),(6.04 ± 0.31) vs (5.16 ± 0.34)] (P ＜ 0.05).The 24,48 h levels of hemoglobin and plasma HCO3-in observation group were significantly higher and the level of urea nitrogen was significantly lower than those in control group[(118 ± 13) g/L vs (87 ± 12) g/L,(123 ± 10) g/L vs (109 ± 11) g/L;(16.0±1.3)mmol/L vs (15.0 ±4.2)mmol/L,(24.0 ±0.9)mmol/L vs (20.0 ±1.2)mmol/L;(6.6 ±3.7) mmol/L vs (8.8 ± 4.6) mmol/L,(4.9 ± 2.3) mmol/L vs (6.8 ± 1.5) mmol/L] (P ＜ 0.05).The total effective rate in observation group was significantly higher than that in control group[95.2％ (20/21) vs 81.0％(17/21)] (P ＜ 0.05).The adverse reaction rate had no significant difference between groups (P ＞ 0.05).Conclusion High dose of intravenous rabeprazole shows acid-suppressive and hemostatic effects on craniocerebral injury patients with upper gastrointestinal bleeding without increasing adverse effects.
Keywords：Craniocerebral traumaUpper gastrointestinal bleedingRabeprazole
Publication Date：2017-11-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 1649-1651 )