Impact of blood glucose variability on left ventricular function in non-diabetic patients with ST-elevation myocardial infarction
Yang Hongxia
Zhang Tao
Su Gong
Mi Shuhua
Jia Shujie
Xin Wei
Wang Yang
Abstract：Objective To explore the impact of blood glucose variability on left ventricular function in non-diabetic patients with ST-elevation myocardial infarction (STEMI).Methods Totally 184 non-diabetic patients with STEMI who had emergency percutaneous coronary intervention(PCI) from January 2016 to February 2017 in Beijing Anzhen Hospital,Capital Medical University were enrolled.All patients were monitored of mean amplitude of plasma glucose(MAGE) and they were divided into low MAGE group (＜ 2.78 mmol/L,n =120)and high MAGE group(≥ 2.78 mmol/L,n =64).General information,laboratory results and echocardiographic findings were recorded.The correlation between MAGE and left ventricular function was analyzed.Results Body mass index,serum levels of total cholesterol and low-density lipoprotein cholesterol in high MAGE group were significantly higher than those in low MAGE group [(27.0 ± 2.2) kg/m2 vs (25.9 ± 2.4) kg/m2,(5.1 ±1.4) mmol/L vs (4.4 ± 0.9) mmol/L,(3.4 ± 1.3) mmol/L vs (2.7 ± 0.7) mmol/L] (P ＜ 0.05).Fasting blood glucose,glycosylated hemoglobin (HbA1c),Killip grade,left ventricular ejection fraction (LVEF) and left ventricular end-diastolic diameter(LVEDD) showed significant differences between groups(P ＜ 0.05).LVEF was negatively correlated with MAGE (r =-0.23,P ＜ 0.05).LVEDD was positively correlated with body mass index and MAGE (r =0.229,P ＜ 0.05;r =0.389,P ＜ 0.001).Killip grade was positively correlated with HbA1c and MAGE (rs =0.37,P ＜ 0.05;rs =0.35,P ＜ 0.05).Multiple linear regression analysis showed that MAGE was an independent risk factor of LVEDD (P ＜ 0.05).Multivariate logistic regression analysis showed that HbA1c and MAGE were independent risk factors of Killip grade(P ＜ 0.05).Conclusion A large fluctuation range of blood glucose is related to deterioration of left ventricular function in patients with STEMI.
Keywords：Myocardial infarctionBlood glucoseVentricular function,left
Publication Date：2017-11-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1601-1604 )