Relation among serum apolipoprotein-A, N-terminal pro-brain nitric peptide, homocysteine and severity of acute cerebral infarction
Pu Yingxiang
Li Yupeng
Xing Chengwen
Li Pengye
Ma Ting
Chen Tingyun
Abstract：Objective To analyze the relation among serum apolipoprotein-A (APO-A),N-terminal probrain nitric peptide(NT-proBNP),homocysteine(Hcy) and severity of acute cerebral infarction.Methods From March 2015 to March 2017,126 patients with acute cerebral infarction were enrolled as observation group and 125 healthy people were enrolled as control group in Renji Hospital of Qinghai Province.According to score of the National Institutes of Health Stroke Scale(NIHSS) at admission,the observation group was divided into mild group (score of NIHSS ＜ 5 points,n =55),moderate group (score of NIHSS 5-15 points,n =36) and severe group (score of NIHSS ＞ 15 points,n =35).According to the score of modified Rankin Scale (mRS) 90 d after discharge,the observation group was divided into good prognosis group(score of mRS≤2 points,n =4) and poor prognosis group(score of mRS ＞ 2 points,n =52).APO-A was tested by immunoturbidimetric assay;NT-proBNP was tested by enzyme linked immunosorbent assay;Hcy was tested by enzymatic cycling assay.The relation among serum levels of APO-A,NT-proBNP,Hcy and severity of acute cerebral infarction (assessed by scores of NIHSS and mRS) was analyzed.Results Levels of APO-A,NT-proBNP and Hcy in observation group were significantly higher than those in control group [(541 ± 128)mg/L vs (205 ± 51)mg/L,(416 ± 91) ng/L vs (50 ± 7)ng/L,(29.6 ± 10.4) μmol/L vs (11.1 ± 1.3) μmol/L] (P ＜ 0.001).Levels of APO-A,NT-proBNP and Hcy increased with the score of NIHSS and there were significant differences among mild group,moderate group and severe group (P ＜ 0.001).Levels of APO-A,NT-proBNP and Hcy in good prognosis group were significantly lower than those in poor prognosis group(P ＜ 0.05).Spearman correlation analysis showed that levels of APO-A,NT-proBNP and Hcy were positively correlated with scores of NIHSS (r =0.521,P =0.009;r =0.615,P =0.008;r =0.571,P =0.009) andmRS (r=0.485,P=0.009;r=0.516,P=0.009;r=0.527,P=0.009).Conclusion Serum levels of APO-A,NT-proBNP and Hcy are related to severity of acute cerebral infarction.
Keywords：Acute cerebral infarctionSeverityApolipoprotein-AN-terminal pro-brain nitric peptideHomocysteine
Publication Date：2017-10-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1515-1519 )