Clinical effects of different doses of rosuvastatin combined with recombinant human tissue plasminogen activator for injection on acute cerebral infarction
Guo Dong
Jin Yong
Jiang Zhilin
Wan Ting
Li Cong
Abstract：Objective To explore clinical effects of different doses of rosuvastatin combined with recombinant human tissue plasminogen activator for injection(rt-PA) on acute cerebral infarction.Methods Eighty-four patients with acute cerebral infarction admitted from July 2014 to March 2016 in Chinese People's Liberation Army No.202 Hospital were randomly divided into observation group and control group,with 42 cases in each group.All patients received antihypertensive and hypolipidemic therapies;the observation group was treated with rt-PA 0.9 mg/kg(the maximum dose≤90 mg) plus rosuvastatin calcium tablets 20 mg/d for 1 month;the control group was treated with same dose of rt-PA plus rosuvastatin calcium tablets 10 mg/d for 1 month.Blood lipid level,scores of the National Institutes of Health Stroke Scale(NIHSS) and Barthel Index(BI) were recorded before and after treatment.The therapeutic effect was analyzed.Results There were no significant differences of total cholesterol (TC),low-density lipoprotein cholesterol(LDL-C) and high-density lipoprotein cholesterol(HDL-C) between groups before treatment(P ＞0.05).After treatment,levels of TC and LDL-C significantly decreased compared to those before treatment in both groups [(3.6 ± 1.4) mmol/L vs (5.7 ± 1.3) mmol/L,(3.0 ± 0.5) mmol/L vs (3.5 ± 1.0) mmol/L;(5.3 ± 1.3) mmol/L vs (5.7 ± 1.3) mmol/L,(3.4 ± 0.7) mmol/L vs (3.5 ± 1.0) mmol/L];there were also significant differences between groups (P ＜ 0.05).The level of HDL-C after treatment showed no significant difference between groups(P ＞ 0.05).Scores of NIHSS and BI had no significant differences between groups before treatment(P ＞ 0.05).After treatment,NIHSS score in observation group was significantly lower and BI score was significantly higher than those in control group [(2.2 ± 1.2) scores vs (4.3 ± 1.4) scores,(66 ±23) scores vs (56 ± 20) scores] (P ＜ 0.05).The total effective rate in observation group was significantly higher than that in control group [92.9％ (39/42) vs 76.2％ (32/42)] (x2 =4.459,P =0.035).Conclusion High dose of rosuvastatin combined with rt-PA can effectively control blood lipid level,promote recovery of neurological deficits and improve ability of daily living in patients with acute cerebral infarction.
Keywords：Acute cerebral infarctionRecombinant human tissue plasminogen activator for injectionRosuvastatin
Publication Date：2017-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1511-1514 )