Early clinical features and changes of cytokines in children with refractory mycoplasma pneumoniae pneumonia
Zheng Mao
Chen Yao
Fu Jia
Abstract：Objective To investigate early clinical features and changes of cytokines in children with refractory mycoplasma pneumoniae pneumonia(RMPP).Methods Clinical data of 50 children with RMPP and 50 children with general mycoplasma pneumoniae pneumonia(GMPP) who were admitted in Xi'an Children's Hospital from December 2013 to December 2016 were retrospectively analyzed.All children had chest X-ray and/or CT scanning,fiberoptic bronchoscopy and bronchoalveolar lavage.Clinical features,X-ray and/or CT findings,bronchoscopic results and levels of interleukin-6 (IL-6),IL-10 and interferon-γ(IFN-γ) in bronchoalveolar lavage fluid(BALF) were analyzed.Results Clinical features (fever,cough,increases of leucocyte count and C-reactive protein),image features (pulmonary consolidation,lobar pneumonia,hilar lymph node enlargement,pleural effusion and atelectasis) and bronchoscopic features (airway mucosal hyperemia and swelling,longitudinal folds,secretion,bronchial stenosis and luminal softening) showed no significant differences between RMPP group and GMPP group(P ＞0.05).Ratios of luminal granulation tissue hyperplasia,airway obstruction by mucus plugs and mucosal erosion observed by bronchoscopy and levels of IL-6 and IFN-γ in BALF in RMPP group were significantly higher than those in GMPP group [16.0％ (8/50) vs 4.0％ (2/50),52.0％ (26/50) vs 26.0％ (13/50),16.0％ (8/50) vs 4.0％ (2/50),(32 ± 5) ng/L vs (17 ± 3) ng/L,(11.7 ± 2.1) ng/L vs (8.0 ± 1.6) ng/L](P ＜0.05);the level of IL-10 in BALF in RMPP group was significantly lower than that in GMPP group[(4.5 ±1.0) ng/L vs (7.6 ± 1.2) ng/L] (P ＜ 0.05).Conclusion There are significant differences of bronchoscopic features and levels of inflammatory cytokines in BALF between children with RMPP and GMPP;early detection of bronchoscopy and cytokines may contribute to predicting the occurrence of RMPP.
Keywords：Mycoplasma pneumoniaeRefractoryCytokines
Publication Date：2017-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1499-1502 )