Effects of loading dose plus high maintenance dose of atorvastatin on vascular endothelial function and cardiac function in patients with acute coronary syndrome
Zhang Liang
Huang Wensheng
Leng Lihua
Abstract：Objective To explore effects of loading dose plus high maintenance dose of atorvastatin on vascular endothelial function and cardiac function in patients with acute coronary syndrome(ACS).Methods Clinical data of 118 patients with ACS who had percutaneous coronary intervention (PCI) from March 2016 to March 2017 in the PLA Navy Anqing Hospital were retrospectively analyzed.The observation group (59 cases) had loading dose plus high maintenance dose of atorvastatin and the control group(59 cases) had routine administration method of atorvastatin during perioperative period of PCI.Biochemical indicators,vascular endothelial function and cardiac function indexes were analyzed.Results One month after discharge,levels of total cholesterol,triacylglycerol,low-density lipoprotein cholesterol in observation group were significantly lower and the level of high-density lipoprotein cholesterol was significantly higher than those in control group (P ＜ 0.05);levels of creatine kinase,creatine kinase isoenzyme,α-hydroxybutyric dehydrogenase,lactate dehydrogenase and high-sensitivity C-reactive protein in observation group were significantly lower than those in control group(P ＜ 0.05);levels of endothelin-1,yon Willebrand factor were significantly lower and nitric oxide was significantly higher than those in control group [(54 ±6)ng/L vs (67 ±7) ng/L,(92 ± 8)％ vs (106 ± 10)％,(78 ± 8) μmol/L vs (67 ±7) μmol/L] (P ＜ 0.05);left ventricular ejection fraction,mitral valve early diastolic blood flow peak velocity/late diastolic blood flow peak velocity ratio in observation group were significantly higher and cardiac function systolic index,diastolic index,myocardial performance index(Tei index) were significantly lower than those in control group [(63 ± 8)％ vs (58±7)％,(1.28±0.21) vs (1.04±0.17),(0.22±0.03) vs (0.28±0.05),(0.24±0.04) vs (0.31 ± 0.06),(0.41 ±0.07) vs (0.53 ±0.08)] (P＜0.05).Conclusion Loading dose plus high maintenance dose of atorvastatin treating patients with ACS can improve cardiac and vascular endothelial function.
Keywords：Acute coronary syndromeAtorvastatinVascular endothelial function
Publication Date：2017-10-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 1478-1482 )