Clinical effects of trimetazidine hydrochloride on female microvascular angina pectoris and exercise tolerance
Li Shihong
Lin Yun
Tao Ying
Gao Yulong
Kang Lihui
Sun Junping
Zhang Jingmei
Li Zhizhong
Abstract：Objective To observe clinical effects of trimetazidine hydrochloride on female microvascular angina pectoris and exercise tolerance.Methods Totally 108 female patients with microvascular angina pectoris who were admitted in Beijing Anzhen Hospital,Capital Medical University from October 2013 to September 2016 were randomly divided into observation group (58 cases) and control group (50 cases).The control group was treated with conventional medicine;the observation group was treated with trimetazidine hydrochloride(20 mg/time,3 times/d,orally) on the basis of control group;both groups were treated for 12 weeks.Clinical efficacy,electrocardiogram,frequency of angina attack and results of treadmill exercise test were analyzed.Results The total clinical effective rate and the ECG effective rate in observation group were significantly higher than those in control group[89.7％ (52/58) vs 58.0％ (29/50),87.9％ (51/58) vs 54.0％ (27/50)] (P ＜ 0.01).After treatment,frequency of angina attack in observation group was significantly less than that in control group;exercise duration,duration of ST segment 1 mm depression and the duration between beginning of treadmill exercise test and attack of angina pectoris in observation group were significantly longer than those in control group;the maximum amphtude of ST segment depression in observation group was significantly lower than that in control group (P ＜ 0.05).Conclusion Trimetazidine hydrochloride treating female microvascular angina pectoris can improve exercise tolerance.
Keywords：Microvascular angina pectorisTrimetazidineExercise tolerance
Publication Date：2017-10-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1475-1478 )