Effects of glycosylated hemoglobin on infarct-related artery flow and prognosis in patients after primary percutaneous coronary intervention for acute myocardial infarction
Gao Yulong
Li Lina
Zhang Jingmei
Tao Ying
Li Zhizhong
Abstract：Objective To investigate effects of glycosylated hemoglobin (HbA1c) on infarct-related artery flow and prognosis in patients after primary percutaneous coronary intervention(PPCI) for acute myocardial infarction(AMI).Methods Clinical data of 502 patients with AMI who had PPCI from January to December 2013 in Beijing Anzhen Hospital,Capital Medical University were retrospectively analyzed.The patients were divided into HbA1 c ≥ 6.5 ％ group (193 cases) and control group (309 cases).Baseline data,results of coronary angiography,operation data and prognosis were analyzed.Results Male rate,left ventricular ejection fraction,postoperative thrombolysis in myocardial infarction (TIMI) grade 3 rate and ST-segment drop rate in HbA1 c ≥6.5％ group were significantly lower than those in control group [66.2％ (128/193) vs 72.1％ (223/309),(50±10)％ vs (53 ± 11)％,92.5％ (179/193) vs 96.7％ (299/309),88.4％ (171/193) vs 93.8％(290/309)] (P ＜ 0.05).Age,hypertension rate,time between AMI attack and admission,time of infarctrelated artery patency,postoperative no reflow/slow flow rate and in-hospital mortality rate in HbA1 c ≥ 6.5％group were significantly higher(longer) than those in control group[(62 ± 10) years vs (61 ± 11)years,(8.4 ±2.1)hvs (7.7 ±2.2)h,(84 ±15)min vs (79 ±12)min,7.5％(14/193) vs 3.3％ (10/309),2.9％(6/193) vs 0.5％ (2/309)] (P ＜0.05).Logistic regression analysis showed that HbA1c was an independent risk factor of in-hospital mortality (odds ratio =2.036,95％ confidence interval:0.977-3.987,P =0.031).Conclusion Patients with high level of HbA1 c have poor heart function and coronary flow after PPCI;HbA1 c is a risk factor of post-PPCI death.
Keywords：Acute myocardial infarctionGlycosylated hemoglobinCoronary interventionInfarct-related artery
Publication Date：2017-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1449-1452 )