Effect of sevoflurane preconditioning on postoperative cognitive function in type 1 diabetic rats
Wang Hainan
Bi Xinwen
Jiang Xiaojing
Abstract：Objective To investigate the effect of sevoflurane preconditioning on postoperative cognitive function in type 1 diabetic rats.Methods A total of 120 male SD rats were randomly divided into control group,operation group,sevoflurane preconditioning group and normal group,with 30 rats in each group.Rats in control group,operation group and sevoflurane preconditioning group were induced type 1 diabetes.The control group had sodium pentobarbital anesthesia without surgery.The operation group had exploratory laparotomy under sodium pentobarbital anesthesia and the operation lasted for 30 min.The sevofiurane preconditioning group and the normal group inhaled 2.4％ sevoflurane 30 rain and pure air 30 min before operation.Morris water maze escape latency and the number of times of crossing original platform were tested 30 rain before and 1,3,7 d after operation.Levels of tumor necrosis factor-u(TNF-ct) and interleukin-1β(IL-1 β) were tested 30 min before and 1,7 d after operation.Results Escape latencies in sevoflurane preconditioning group were significantly longer than those in normal group at 30 min before and 1,3,7 d after operation[(24.0 ±2.2)s vs (20.2 ± 1.8)s,(42.6 ±5.6)s vs (32.5 ± 3.0) s,(32.6 ± 4.2) s vs (26.2 ± 2.6) s,(26.5 ± 2.8) s vs (24.8 ± 2.0) s];escape latencies 1,3,7 d after operation in sevoflurane preconditioning group were significantly longer than those in control group [(24.0 ± 2.4) s,(23.6 ± 2.2) s,(24.4 ± 2.3) s] and shorter than those in operation group [(70.6 ± 5.8) s,(46.8 ± 5.1) s,(34.5 ± 3.6) s] (P ＜ 0.05).Times of crossing original platform in sevoflurane preconditioning group were significantly less than those in normal group and control group at 1,3 d after operation [(6.8 ± 3.0)timesvs (14.2±3.6)times,(13.0±3.2)times;(10.2±2.5)times vs (13.5±3.0)times,(14.2± 4.0)times];times of crossing original platform 30 min before and 1,3,7 d after operation in sevoflurane preconditioning group were significantly more than those in operation group [(14.0 ± 2.8) times vs (12.6 ± 3.3)times,(6.8±3.0)times vs (4.2± 1.5)times,(10.2 ±2.5)times vs (6.5 ±2.0)times,(15.2± 3.5) times vs (9.5 ± 2.5) times] (P ＜ 0.05).Levels of TNF-α and IL-1 β 30 min before and 1,7 d after operation in sevoflurane preconditioning group were significantly lower than those in normal group,control group and operation group (P ＜ 0.05).Conclusion Sevoflurane preconditioning can reduce the incidence of postoperative cognitive dysfunction in type 1 diabetic rats.
Keywords：Sevoflurane preconditioningDiabetes mellitusCognitive function
Publication Date：2017-09-30
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1360-1363 )