Application value of S100A9 protein in progression monitoring of secondary pulmonary tuberculosis
Liu Qiuyue
Pan Liping
Luo Baojian
Han Fen
Zhang Zongde
Li Qi
Abstract：Objective To explore the application value of S100A9 protein in monitoring the progression of secondary pulmonary tuberculosis.Methods Totally 143 patients with secondary pulmonary tuberculosis from March to December 2015 in Beijing Tuberculosis and Thoracic Tumor Research Institute were divided into severe group (72 cases) and mild group(71 cases);41 healthy people were enrolled as control group.The plasma concentration of S100A9 protein was tested by enzyme linked immunosorbent assay;the level of high sensitivity C-reactive protein (hs-CRP) was tested by immunoturbidimetry;erythrocyte sedimentation rate (ESR) was tested by Westergren method.The relevance among S100A9 protein,hs-CPR,ESR and the severity of secondary pulmonary tuberculosis was analyzed.Results Levels of S100A9 protein,hs-CRP and ESR in severe group were significantly higher than those in mild group and control group (P ＜ 0.05).Multivariate logistic regression analysis showed that S100A9 protein and ESR were independent risk factors of severe pulmonary tuberculosis (P ＜ 0.05).The sensitivity and specificity of S100A9 protein in differential diagnosis of severe and mild pulmonary tuberculosis were 91.5％ and 86.7％,respectively.Conclusion Detection of plasma S100A9 protein level helps monitoring the progression of secondary pulmonary tuberculosis.
Keywords：Pulmonary tuberculosisS100A9 proteinSeverity of disease
Publication Date：2017-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：3( 1326-1328 )