Clinical features of cardiac manifestations in patients with Takayasu's arteritis in different genders
Wan Jin
Pan Lili
Ci Weiping
Liao Hua
Yang Chun
Wang Tian
Abstract：Objective To investigate clinical features of cardiac damage in patients with Takayasu's Arteritis(TA) in different genders.Methods Clinical data of 82 patients with TA from January 2004 to January 2015 in Beijing Anzhen Hospital,Capital Medical University were analyzed retrospectively.Cardiac impairment was assessed by imaging examination;general data,clinical manifestations,laboratory indicators,vascular involvements,clinical classification and echocardiographic findings were analyzed in TA patients with cardiac damage.Results There were 63.4％ (52/82) of TA complicated with cardiac damage,including 6 males and 46 females.The onset age and the duration between onset and diagnosis had no significant differences between male and female (P ＞ 0.05).The proportion of upper limbs blood pressure difference ≥ 10 mmHg in male was significantly lower than that in female [1/6 vs 73.9％ (34/46)] (P ＜ 0.05).The proportion of C-reactive protein elevation in male was significantly higher than that in female[6/6 vs 50.0％ (23/46)] (P ＜0.05).The proportion of erythrocyte sedimentation rate elevation had no significant difference between male and female(P ＞ 0.05).The incidence of left subclavian artery stenosis or occlusion in male was significantly lower than that in female [0/6 vs 69.6％ (32/46)] (P ＜ 0.05).The clinical classification had no significant difference between male and female(P ＞ 0.05).The left ventricular ejection fraction in male was lower and the incidence of left ventricular diastolic dysfunction was higher than those in female [(54 ± 15) ％ vs (64 ± 9) ％,6/6 vs 32.6％ (15/46)] (P ＜ 0.05).The incidence of myocardial lesions in male was significantly higher than that in female [2/6 vs 4.3％ (2/46)] (P ＜ 0.05).Conclusion Cardiac damage in male patients with TA mainly manifests myocardial lesions and left ventrictdar diastolic dysfunction;it in female patients mainly manifests left subclavian artery lesions.
Keywords：Takayasu's arteritisCardiac damageGender
Publication Date：2017-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：4( 1310-1313 )